Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)

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Cell Small Molecule Treatment Duration GR50 GRmax GR_AOC GEC50 GRinf hGR
HCC202 HY-17542 72
68.7359336666
 0.6087 0.0718 43.2417 0.3314 2.3458
PDXHCI002 IU1 72
inf
 0.7347 0.0713 0.0000 0.9096 0.0100
T47D 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9421 0.0700 0.0000 0.9383 0.0100
HCC202 Doxycycline 72
41.0834372075
 0.2347 0.0694 58.6649 -1.0000 3.0839
PDX1258 z-VAE(OMe)-fmk 72
inf
 0.9262 0.0692 0.0000 0.9516 0.0100
PDXHCI002 USP7-IN-1 72
inf
 0.8827 0.0691 0.0000 0.9313 0.0100
PDX1258 USP7-IN-1 72
inf
 0.8007 0.0688 0.0000 0.9245 0.0100
HCC1428 USP7-IN-1 72
inf
 0.6846 0.0667 0.0000 0.9252 0.0100
SK-BR-3 ML-323 72
71.5457262907
 0.6083 0.0659 250.9976 -1.0000 0.8753
BT-20 ML-323 72
211.396631725
 0.7311 0.0653 1563.4058 -1.0000 0.5491
HCC1428 STK547622 72
inf
 0.8677 0.0634 0.0000 0.9587 0.0100
BT-20 HBX19818 72
30.8921915642
 -0.2433 0.0631 35.1813 -0.4578 5.0000
HCC1500 USP7-IN-1 72
51.9923039456
 0.4861 0.0630 130.5080 -1.0000 1.1937
MDA-MB-361 HBX19818 72
20.1726714877
 -0.3872 0.0630 34.0507 -1.0000 2.0985
MDA-MB-134-VI ML-323 72
45.5586104943
 0.3266 0.0626 58.1271 -1.0000 4.5093
T47D SB1-F-22 72
156.804339896
 0.7134 0.0621 286.2396 -0.2481 0.6696
MDA-MB-231 IU1 72
inf
 0.8503 0.0614 0.0000 0.9320 0.0100
MDA-MB-134-VI HY-17542 72
inf
 0.5701 0.0598 0.0000 0.9013 0.0100
SK-BR-3 USP7-IN-1 72
62.2210904101
 0.5764 0.0588 133.0943 -1.0000 1.4449
PDXHCI002 z-VAE(OMe)-fmk 72
inf
 0.9278 0.0585 0.0000 0.9445 0.0100
HCC1428 z-VAE(OMe)-fmk 72
inf
 0.9944 0.0566 0.0000 0.9577 0.0100
CAMA-1 SB1-F-22 72
43.6088606735
 0.4408 0.0565 156.5267 -1.0000 0.8597
MCF 10A SB1-F-22 72
inf
 0.6491 0.0559 11.0527 0.6904 5.0000
Hs 578T SB1-F-22 72
48.629206693
 0.4746 0.0557 108.1899 -1.0000 1.3738
HCC1954 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.8537 0.0553 0.0000 0.9409 0.0100