Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDXHCI002 | Pimozide | 72 | 3.73166784701 | -0.4762 | 0.4161 | 6.9559 | -0.6294 | 1.3085 |
| HCC202 | HY-17541A | 72 | 7.97410131961 | -0.7625 | 0.4142 | 15.8638 | -0.9318 | 1.5296 |
| HCC1428 | Pimozide | 72 | 5.48832397235 | -0.7126 | 0.4005 | 12.0349 | -1.0000 | 1.3992 |
| HCC1954 | P22077 | 72 | 3.99414837065 | -0.8173 | 0.3966 | 8.7096 | -0.9912 | 1.4017 |
| MDA-MB-231 | HBX 41108 | 72 | 3.79238934604 | -0.3900 | 0.3944 | 5.0207 | -0.4010 | 2.0990 |
| T47D | HY-50737A | 72 | 4.05537288518 | -0.2242 | 0.3936 | 4.4286 | -0.2752 | 4.9803 |
| HCC1500 | Trifluoperazine | 72 | 6.81100307422 | -0.8014 | 0.3931 | 10.4325 | -0.8483 | 2.3266 |
| PDX1258 | Pimozide | 72 | 5.06894491311 | -0.3597 | 0.3871 | 19.1221 | -1.0000 | 0.8274 |
| MDA-MB-231 | HY-17541A | 72 | 4.06512520453 | -0.5762 | 0.3840 | 10.2476 | -0.9077 | 1.1195 |
| HCC1419 | HY-17541A | 72 | 5.08410753288 | -0.7228 | 0.3771 | 13.2847 | -1.0000 | 1.1438 |
| MCF 10A | HY-50737A | 72 | 2.96132660648 | -0.0560 | 0.3759 | 3.0430 | -0.0720 | 4.9454 |
| HCC1428 | Trifluoperazine | 72 | 7.02071798246 | -0.7839 | 0.3754 | 12.0126 | -0.9425 | 1.9727 |
| T47D | Trifluoperazine | 72 | 7.53715146312 | -0.4917 | 0.3754 | 11.9806 | -0.6568 | 1.8099 |
| MDA-MB-231 | Trifluoperazine | 72 | 10.5680484493 | -0.5359 | 0.3729 | 12.2172 | -0.5163 | 4.8917 |
| BT-20 | P22077 | 72 | 5.68690045385 | -0.8029 | 0.3725 | 7.9927 | -0.8136 | 2.8380 |
| PDX1258 | HY-17541A | 72 | 4.88569792161 | -0.6381 | 0.3717 | 13.5459 | -1.0000 | 1.0773 |
| HCC1954 | SJB2-043 | 72 | 1.24122713519 | -0.3522 | 0.3712 | 1.3752 | -0.2369 | 3.7831 |
| HCC1500 | Pimozide | 72 | 6.78743066265 | -0.5563 | 0.3689 | 15.8355 | -1.0000 | 1.2968 |
| PDX1328 | Trifluoperazine | 72 | 10.4012800704 | -0.9795 | 0.3652 | 12.9427 | -0.9916 | 5.0000 |
| HCC1419 | Pimozide | 72 | 6.13162921953 | -0.7003 | 0.3602 | 13.2581 | -1.0000 | 1.4246 |
| MDA-MB-361 | Degrasyn | 72 | 4.30347364647 | -0.6620 | 0.3590 | 5.1207 | -0.6042 | 4.5568 |
| HCC1500 | Spautin-1 | 72 | 3.41360576159 | -0.0935 | 0.3577 | 5.5741 | -0.2758 | 0.8959 |
| T47D | Pimozide | 72 | 7.11853496187 | -0.5532 | 0.3575 | 16.3429 | -1.0000 | 1.3219 |
| PDX1328 | HY-17541A | 72 | 6.04754155289 | -0.9724 | 0.3564 | 13.0481 | -1.0000 | 1.4286 |
| PDX1328 | Vialinin A | 72 | 6.5234902309 | -0.8259 | 0.3553 | 12.0354 | -0.9870 | 1.7796 |