Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1937 | PB49673382 | 72 | 7.51602525958 | 0.2509 | 0.2135 | 5.4225 | 0.2446 | 2.0574 |
| MCF 10A | P22077 | 72 | 4.7951144345 | -0.3461 | 0.3384 | 5.2700 | -0.2789 | 4.6944 |
| MCF 10A | PB49673382 | 72 | 5.3905505782 | 0.0428 | 0.2622 | 5.1937 | 0.0339 | 1.8897 |
| MDA-MB-361 | SB1-F-22 | 72 | 89.7808679432 | 0.3965 | 0.0864 | 5.1416 | 0.4877 | 1.2948 |
| MDA-MB-361 | Degrasyn | 72 | 4.30347364647 | -0.6620 | 0.3590 | 5.1207 | -0.6042 | 4.5568 |
| HCC1428 | P22077 | 72 | 3.38223139313 | -0.8186 | 0.5185 | 5.0583 | -0.8189 | 2.4098 |
| PDX1258 | PB49673382 | 72 | 5.45211284753 | 0.1759 | 0.2476 | 5.0473 | 0.1600 | 5.0000 |
| MDA-MB-231 | HBX 41108 | 72 | 3.79238934604 | -0.3900 | 0.3944 | 5.0207 | -0.4010 | 2.0990 |
| MDA-MB-231 | LDN57444 | 72 | 4.94637461912 | -0.0113 | 0.2894 | 4.9647 | -0.0024 | 1.2750 |
| PDXHCI002 | SB1-F-22 | 72 | inf | 0.7782 | 0.0455 | 4.9366 | 0.7857 | 0.8521 |
| BT-549 | PB49673382 | 72 | 4.76901821965 | -0.0004 | 0.2990 | 4.7981 | -0.0079 | 2.5928 |
| HCC1806 | MI-2 | 72 | 3.9059429509 | -0.5803 | 0.4525 | 4.7751 | -0.5651 | 3.7640 |
| T47D | P22077 | 72 | 3.7378149825 | -0.5532 | 0.4192 | 4.7330 | -0.5353 | 3.0835 |
| MDA-MB-361 | MI-2 | 72 | 3.80487472111 | -0.7848 | 0.4779 | 4.6826 | -0.7574 | 4.4428 |
| PDX1258 | P22077 | 72 | 3.1997536366 | -0.5772 | 0.4517 | 4.5424 | -0.5888 | 2.2210 |
| MCF 10A | Spautin-1 | 72 | inf | 0.7020 | 0.0777 | 4.4596 | 0.7090 | 1.5877 |
| T47D | HY-50737A | 72 | 4.05537288518 | -0.2242 | 0.3936 | 4.4286 | -0.2752 | 4.9803 |
| PDXHCI002 | Trifluoperazine | 72 | 3.81665897006 | -0.5151 | 0.4939 | 4.3815 | -0.4970 | 5.0000 |
| HCC1806 | SJB2-043 | 72 | 4.05064367394 | -0.1302 | 0.2617 | 4.3188 | -0.1361 | 3.7560 |
| SK-BR-3 | PB49673382 | 72 | 4.13146034734 | 0.0664 | 0.3312 | 3.9132 | 0.0565 | 2.2078 |
| HCC1954 | Degrasyn | 72 | 3.28733078255 | -0.6866 | 0.5156 | 3.9070 | -0.6857 | 5.0000 |
| T47D | PB49673382 | 72 | 3.64102000587 | -0.0634 | 0.3384 | 3.7853 | -0.0626 | 3.0337 |
| T47D | Spautin-1 | 72 | 6.81498097187 | 0.2682 | 0.2402 | 3.7541 | 0.2153 | 0.9443 |
| HCC1954 | Spautin-1 | 72 | 6.85692752046 | 0.2805 | 0.2576 | 3.7201 | 0.1916 | 0.7903 |
| Hs 578T | HY-17541A | 72 | 2.67034332565 | -0.5936 | 0.4776 | 3.6894 | -0.5809 | 2.3850 |