Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HBX 41108 | 72 | 2.76621539192 | -0.6472 | 0.4718 | 6.2693 | -0.8129 | 1.1799 |
| MDA-MB-134-VI | USP7-IN-1 | 72 | inf | 0.7107 | 0.0309 | 0.0000 | 0.9508 | 0.0100 |
| MDA-MB-134-VI | PB49673382 | 72 | 12.4536117294 | -0.0102 | 0.1233 | 11.0745 | 0.2220 | 5.0000 |
| MDA-MB-134-VI | 1247825-37-1 | 72 | 10.4154396199 | -0.1095 | 0.2026 | 10.7700 | -0.0911 | 5.0000 |
| MDA-MB-134-VI | HY-17541A | 72 | 7.95461844294 | -0.9278 | 0.2754 | 16.0755 | -1.0000 | 1.5615 |
| MDA-MB-134-VI | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.1199 | 0.1894 | 0.0000 | 0.8466 | 0.0100 |
| MCF7 | ML-323 | 72 | 34.9041902184 | 0.3934 | 0.1213 | 138.0045 | -1.0000 | 0.7992 |
| MCF7 | Pevonedistat | 72 | 0.150383057079 | -0.0374 | 0.6766 | 0.1518 | -0.0061 | 1.3103 |
| MCF7 | MI-2 | 72 | 6.8346316028 | -0.3570 | 0.2990 | 9.1547 | -0.4209 | 2.0896 |
| MCF7 | PB49673382 | 72 | 5.67599742388 | -0.0650 | 0.2629 | 5.9577 | -0.0564 | 2.2057 |
| MCF7 | HY-50737A | 72 | 0.230613494355 | -0.1986 | 0.7394 | 0.3067 | -0.2336 | 1.3443 |
| MCF7 | IU1 | 72 | inf | 0.7464 | 0.0252 | 29.2117 | 0.7291 | 5.0000 |
| MCF7 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0084 | -0.0062 | 0.0000 | 1.0000 | 0.0100 |
| MCF7 | LDN57444 | 72 | 39.229352909 | 0.3803 | 0.0338 | 32.3166 | 0.3103 | 5.0000 |
| MCF7 | HBX 41108 | 72 | 0.390147535667 | -0.2149 | 0.6730 | 0.5376 | -0.2563 | 1.2906 |
| MCF7 | HY-17541A | 72 | 7.73553288527 | -0.3502 | 0.2614 | 22.0378 | -0.9606 | 1.0240 |
| MCF7 | HBX19818 | 72 | 22.3259717989 | -0.2798 | 0.1315 | 35.8197 | -0.8671 | 2.1277 |
| MCF7 | HY-17542 | 72 | inf | 0.9160 | 0.0071 | 30.5166 | 0.9088 | 5.0000 |
| MCF7 | USP7-IN-1 | 72 | inf | 0.6288 | 0.0309 | 31.6085 | 0.5581 | 3.6163 |
| MCF7 | HY-50736 | 72 | 0.048225043242 | -0.1348 | 0.9464 | 0.0630 | -0.2053 | 1.2899 |
| MCF7 | SB1-F-21 | 72 | 0.615140979311 | -0.3940 | 0.6577 | 0.7749 | -0.3444 | 2.2705 |
| MCF7 | GW7647 | 72 | 67.0602654387 | 0.8376 | -0.0104 | 77.7420 | -0.5174 | 4.8064 |
| MCF7 | 1247825-37-1 | 72 | 11.3527817708 | -0.0635 | 0.1793 | 13.0348 | -0.1527 | 1.9288 |
| MCF7 | SB1-F-22 | 72 | 13.3623714813 | 0.2021 | 0.1288 | 11.5010 | 0.2638 | 5.0000 |
| MCF7 | z-VAE(OMe)-fmk | 72 | inf | 1.0118 | -0.0177 | 0.0000 | 1.0000 | 0.0100 |