Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | SB1-F-22 | 72 | 59.7536343747 | 0.4976 | 0.1006 | 10.5121 | 0.4603 | 1.4571 |
| SK-BR-3 | SJB2-043 | 72 | 0.397342856958 | -0.6773 | 0.7194 | 0.5909 | -0.6730 | 2.1483 |
| SK-BR-3 | SJB3-019A | 72 | 0.215693673039 | -0.7085 | 1.0151 | 0.2978 | -0.6932 | 2.6978 |
| SK-BR-3 | STK547622 | 72 | inf | 0.9373 | 0.0215 | 0.0000 | 0.9814 | 0.0100 |
| SK-BR-3 | Vialinin A | 72 | 6.57450356831 | -0.4313 | 0.2897 | 11.2296 | -0.5685 | 1.4185 |
| SK-BR-3 | Degrasyn | 72 | 1.46725479038 | -0.5284 | 0.5755 | 2.0646 | -0.5400 | 2.1444 |
| SK-BR-3 | Sepantronium | 72 | 0.0223899931737 | -0.6896 | 1.3675 | 0.0376 | -0.6471 | 1.6002 |
| SK-BR-3 | b-AP15 | 72 | 0.0708405930018 | -0.6425 | 1.0904 | 0.1445 | -0.6152 | 1.1256 |
| SK-BR-3 | Doxycycline | 72 | 30.0303971358 | 0.1295 | 0.1243 | 58.5093 | -1.0000 | 1.6472 |
| SK-BR-3 | Mitoxantrone | 72 | 0.00831816680715 | -0.7263 | 1.2354 | 0.0647 | -0.7477 | 0.4458 |
| SK-BR-3 | P22077 | 72 | 7.32594313781 | -0.7339 | 0.3405 | 11.7189 | -0.8571 | 2.1255 |
| SK-BR-3 | Pimozide | 72 | 4.05486946769 | -0.5520 | 0.4336 | 12.8412 | -1.0000 | 0.9530 |
| SK-BR-3 | Spautin-1 | 72 | 52.4840202993 | 0.5136 | 0.1207 | 9.4550 | 0.4402 | 1.2389 |
| SK-BR-3 | Trifluoperazine | 72 | 8.87780846384 | -0.7359 | 0.3201 | 12.7153 | -0.8135 | 2.6884 |
| SK-BR-3 | z-VAE(OMe)-fmk | 72 | inf | 0.9573 | 0.0430 | 0.0000 | 0.9575 | 0.0100 |
| T47D | 1247825-37-1 | 72 | 11.5296139364 | -0.2221 | 0.1900 | 12.3560 | -0.2068 | 5.0000 |
| T47D | USP7-IN-1 | 72 | 35.2358506575 | 0.3921 | 0.1491 | 300.7608 | -1.0000 | 0.5124 |
| T47D | GW7647 | 72 | 29.2962645783 | -0.3773 | 0.0975 | 40.0903 | -1.0000 | 3.5024 |
| T47D | HBX19818 | 72 | 19.8447349854 | -0.2828 | 0.1712 | 37.7631 | -1.0000 | 1.7075 |
| T47D | HBX 41108 | 72 | 1.00606977934 | -0.4470 | 0.6172 | 1.2542 | -0.4170 | 2.7516 |
| T47D | HY-17541A | 72 | 6.09725713645 | -0.5568 | 0.3223 | 17.5481 | -1.0000 | 1.0393 |
| T47D | HY-17542 | 72 | 60.7583842474 | 0.5918 | 0.0384 | 120.2191 | -1.0000 | 1.6099 |
| T47D | HY-50736 | 72 | 0.739108069654 | -0.3225 | 0.6531 | 0.9282 | -0.3566 | 2.3631 |
| T47D | HY-50737A | 72 | 4.05537288518 | -0.2242 | 0.3936 | 4.4286 | -0.2752 | 4.9803 |
| T47D | IU1 | 72 | inf | 0.5230 | 0.0543 | 0.0000 | 0.9042 | 0.0100 |