Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| CAL-51 | Vorinostat | HDAC | Misc | 1.8294 | -0.0506 | 0.1862 | 0.0337 | 1.4510 | 2.2081 | 0.98967 |
| HCC1937 | Vorinostat | HDAC | Misc | 1.9099 | -0.0085 | 0.1933 | 0.0353 | 1.4929 | 2.1786 | 0.99505 |
| MDA-MB-134-VI | Vorinostat | HDAC | Misc | 2.4577 | -0.5014 | 0.1748 | 0.0365 | 5.0000 | 2.8258 | 0.99386 |
| MDA-MB-468 | Vorinostat | HDAC | Misc | 1.5734 | -0.1191 | 0.2172 | 0.0608 | 1.9840 | 1.8053 | 0.99971 |
| HCC1419 | Vorinostat | HDAC | Misc | 1.735 | -0.2557 | 0.1917 | 0.0407 | 2.1116 | 2.1704 | 0.99173 |
| HCC1500 | Vorinostat | HDAC | Misc | 0.95606 | -0.5960 | 0.3173 | 0.1165 | 1.0951 | 2.5286 | 0.99617 |
| HCC38 | Vorinostat | HDAC | Misc | 0.95999 | -0.2851 | 0.2909 | 0.1227 | 1.6239 | 1.3226 | 0.99701 |
| PDX1328 | Vorinostat | HDAC | Misc | 0.41708 | -0.5588 | 0.4597 | 0.0854 | 1.1909 | 0.83181 | 0.99216 |
| MDA-MB-157 | Vorinostat | HDAC | Misc | 1.0981 | -0.4130 | 0.2980 | 0.0489 | 1.0997 | 2.487 | 0.9968 |
| MDA-MB-453 | Vorinostat | HDAC | Misc | 0.9215 | -0.6076 | 0.3291 | 0.1421 | 3.3225 | 1.1628 | 0.99512 |
| HCC1395 | Vorinostat | HDAC | Misc | 3.2812 | -0.0589 | 0.1137 | 0.0365 | 2.1496 | 3.8175 | 0.99171 |
| SK-BR-3 | Vorinostat | HDAC | Misc | 0.7625 | -0.6322 | 0.3637 | 0.1534 | 2.3291 | 1.0657 | 0.99404 |
| PDX1258 | Vorinostat | HDAC | Misc | 1.5746 | -0.0232 | 0.2113 | 0.0249 | 1.3725 | 1.8225 | 0.99287 |
| HCC1806 | Vorinostat | HDAC | Misc | 1.1276 | 0.0178 | 0.2397 | 0.0491 | 1.3263 | 1.2167 | 0.99564 |
| BT-549 | Vorinostat | HDAC | Misc | 2.3739 | 0.1131 | 0.1887 | 0.0291 | 0.8756 | 3.9571 | 0.99525 |
| MCF7 | Vorinostat | HDAC | Misc | 0.54198 | -0.1752 | 0.3494 | 0.0792 | 1.1946 | 0.72813 | 0.99735 |
| MDA-MB-231 | Vorinostat | HDAC | Misc | 1.2388 | -0.3848 | 0.2821 | 0.1116 | 1.7685 | 1.7699 | 0.99365 |
| BT-20 | Vorinostat | HDAC | Misc | 2.217 | -0.1134 | 0.1610 | 0.0705 | 1.6271 | 2.8626 | 0.99345 |
| Hs 578T | Vorinostat | HDAC | Misc | 0.90288 | -0.1689 | 0.2728 | 0.1049 | 2.2431 | 1.0225 | 0.99568 |
| HCC70 | Vorinostat | HDAC | Misc | 0.40578 | -0.4765 | 0.4082 | 0.0748 | 0.8914 | 1.0253 | 0.99218 |
| MDA-MB-361 | Vorinostat | HDAC | Misc | 0.76224 | -0.9392 | 0.4607 | 0.1761 | 2.2187 | 1.2401 | 0.99784 |
| MDA-MB-436 | Vorinostat | HDAC | Misc | 2.6793 | 0.0330 | 0.1632 | 0.0301 | 1.6566 | 2.98 | 0.99632 |
| MCF 10A | Vorinostat | HDAC | Misc | 2.5293 | 0.0566 | 0.1675 | 0.0065 | 1.2709 | 3.1489 | 0.99982 |
| CAL-120 | Vorinostat | HDAC | Misc | 1.3545 | -0.2281 | 0.2409 | 0.0682 | 1.2739 | 2.1265 | 0.9951 |
| HCC1954 | Vorinostat | HDAC | Misc | 1.426 | -0.1401 | 0.2339 | 0.0833 | 1.2390 | 2.0871 | 0.99732 |