Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1258 Volasertib
PLK
Cell cycle
0.0073734
 -0.2320 0.5602 0.1765 1.8198
0.0083258
0.98847
HCC1428 Volasertib
PLK
Cell cycle
0.018634
 -0.0388 0.4063 0.0917 2.1456
0.018507
0.99276
HCC1143 Volasertib
PLK
Cell cycle
0.0045882
 -0.3453 0.7290 0.2418 1.8336
0.005996
0.99928
MDA-MB-453 Volasertib
PLK
Cell cycle
0.0071952
 -0.2013 0.5350 0.1191 2.7557
0.0074665
0.98353
MCF7 Volasertib
PLK
Cell cycle
0.0028671
 -0.0338 0.6070 0.1245 4.2176
0.002824
0.99423
HCC38 Vorinostat
HDAC
Misc
0.95999
 -0.2851 0.2909 0.1227 1.6239
1.3226
0.99701
MDA-MB-157 Vorinostat
HDAC
Misc
1.0981
 -0.4130 0.2980 0.0489 1.0997
2.487
0.9968
SK-BR-3 Vorinostat
HDAC
Misc
0.7625
 -0.6322 0.3637 0.1534 2.3291
1.0657
0.99404
HCC70 Vorinostat
HDAC
Misc
0.40578
 -0.4765 0.4082 0.0748 0.8914
1.0253
0.99218
MDA-MB-436 Vorinostat
HDAC
Misc
2.6793
 0.0330 0.1632 0.0301 1.6566
2.98
0.99632
HCC1954 Vorinostat
HDAC
Misc
1.426
 -0.1401 0.2339 0.0833 1.2390
2.0871
0.99732
BT-20 Vorinostat
HDAC
Misc
2.217
 -0.1134 0.1610 0.0705 1.6271
2.8626
0.99345
MCF 10A Vorinostat
HDAC
Misc
2.5293
 0.0566 0.1675 0.0065 1.2709
3.1489
0.99982
MDA-MB-361 Vorinostat
HDAC
Misc
0.76224
 -0.9392 0.4607 0.1761 2.2187
1.2401
0.99784
CAL-85-1 Vorinostat
HDAC
Misc
1.1999
 -0.1827 0.2194 0.0392 1.8241
1.4346
0.98796
SUM149PT Vorinostat
HDAC
Misc
1.3518
 -0.0716 0.2279 0.0446 1.5465
1.5699
0.9993
HCC1143 Vorinostat
HDAC
Misc
0.91041
 -0.2533 0.2953 0.0977 1.9423
1.1249
0.99293
PDXHCI002 Vorinostat
HDAC
Misc
0.28215
 -0.5830 0.5449 0.2572 1.5567
0.47533
0.99111
MDA-MB-453 Vorinostat
HDAC
Misc
0.9215
 -0.6076 0.3291 0.1421 3.3225
1.1628
0.99512
HCC1395 Vorinostat
HDAC
Misc
3.2812
 -0.0589 0.1137 0.0365 2.1496
3.8175
0.99171
SUM159PT Vorinostat
HDAC
Misc
1.9985
 0.1195 0.1810 0.0216 1.3229
1.9352
0.99956
HCC1806 Vorinostat
HDAC
Misc
1.1276
 0.0178 0.2397 0.0491 1.3263
1.2167
0.99564
PDX1328 Vorinostat
HDAC
Misc
0.41708
 -0.5588 0.4597 0.0854 1.1909
0.83181
0.99216
HCC1428 Vorinostat
HDAC
Misc
0.83512
 -0.4792 0.3399 0.1022 1.4868
1.371
0.99679
SUM1315MO2 Vorinostat
HDAC
Misc
1.7621
 -0.0668 0.1742 0.0660 2.7811
1.8526
0.9927