Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
BT-20 Trametinib
MEK
MAPK/nRTK
2.3446
 0.5034 0.1768 0.0535 0.6346
0.053945
0.96232
CAL-51 Trametinib
MEK
MAPK/nRTK
Inf
 0.7064 0.0662 0.0124 0.8944
0.19105
0.98439
MDA-MB-134-VI Trametinib
MEK
MAPK/nRTK
0.0020578
 -0.2707 0.7601 0.0782 1.0824
0.0028809
0.99008
MDA-MB-468 Trametinib
MEK
MAPK/nRTK
0.4421
 0.4075 0.2132 0.0255 0.4592
0.27448
0.99227
HCC1806 Trametinib
MEK
MAPK/nRTK
Inf
 0.7036 0.1086 0.0280 4.8006
0.007609
0.89189
HCC1954 Trametinib
MEK
MAPK/nRTK
0.016729
 0.2287 0.4005 0.0565 0.8524
0.0082359
0.9993
CAMA-1 Trametinib
MEK
MAPK/nRTK
4.9546
 0.5526 0.1688 0.0031 0.5322
0.09227
0.9741
PDX1328 Trametinib
MEK
MAPK/nRTK
0.018054
 0.2490 0.3349 0.0167 1.3148
0.0076303
0.97089
HCC1500 Trametinib
MEK
MAPK/nRTK
0.14491
 0.3439 0.2190 0.0408 0.9370
0.049167
0.9913
Hs 578T Trametinib
MEK
MAPK/nRTK
0.0063584
 0.1931 0.4907 0.0713 0.9022
0.0036513
0.99154
SK-BR-3 Trametinib
MEK
MAPK/nRTK
Inf
 0.6828 0.1817 0.0154 1.1257
0.0059643
0.93505
CAL-85-1 Trametinib
MEK
MAPK/nRTK
0.013202
 0.2343 0.4101 0.1186 0.9630
0.007054
0.99004
PDX1258 Trametinib
MEK
MAPK/nRTK
Inf
 0.8500 0.0424 0.0050 4.9997
0.028253
0.88698
HCC1937 Trametinib
MEK
MAPK/nRTK
Inf
 0.6885 0.1384 0.0485 1.0415
0.012758
0.98277
MCF 10A Trametinib
MEK
MAPK/nRTK
0.0033619
 0.2252 0.5266 -0.0015 1.2096
0.0021432
0.99763
HCC1143 Trametinib
MEK
MAPK/nRTK
0.0088297
 -0.0225 0.5379 0.1187 0.5756
0.013291
0.99613
HCC70 Trametinib
MEK
MAPK/nRTK
0.0019047
 -0.0393 0.6924 0.1954 0.8693
0.0021049
0.98467
MDA-MB-231 Trametinib
MEK
MAPK/nRTK
0.0026306
 -0.1785 0.7224 0.2816 1.1618
0.0033911
0.99829
HCC38 Trametinib
MEK
MAPK/nRTK
0.22023
 0.1854 0.2076 0.0234 0.6910
0.35783
0.98881
HCC1419 Trametinib
MEK
MAPK/nRTK
0.031029
 0.4259 0.2875 -0.0031 1.4893
0.0089457
0.98063
SUM159PT Trametinib
MEK
MAPK/nRTK
0.0055877
 0.2792 0.4613 0.0039 0.9923
0.0023029
0.99862
SUM1315MO2 Trametinib
MEK
MAPK/nRTK
0.021115
 0.1329 0.3887 0.0532 1.0540
0.01638
0.99458
HME1 Trametinib
MEK
MAPK/nRTK
0.0057339
 0.2032 0.4387 0.0257 2.4280
0.0044228
0.99436
HCC1428 Trametinib
MEK
MAPK/nRTK
Inf
 0.8152 0.0767 0.0025 5.0000
0.024413
0.9037
T47D Trametinib
MEK
MAPK/nRTK
Inf
 0.5801 0.2130 0.0041 0.9941
0.0048584
0.90394