Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-468 Ceritinib
ALK
RTK
0.76749
 -0.7415 0.4050 0.1730 1.6622
1.3833
0.99574
HCC1428 Doxorubicin
Chemo
Chemotherapy
0.0047408
 -0.7396 0.8955 0.2242 0.5182
0.029971
0.95944
BT-20 Ceritinib
ALK
RTK
1.5315
 -0.7365 0.2591 0.1255 1.7439
2.7905
0.99717
HCC1500 ABT-737
Bcl2/XL
Misc
0.0085142
 -0.7359 1.1288 0.3716 0.9283
0.022222
0.99554
HCC70 Buparlisib
pan PI3K
PI3K/mTOR
0.43342
 -0.7274 0.4614 0.1434 1.1927
1.0047
0.99537
MDA-MB-361 Doxorubicin
Chemo
Chemotherapy
0.012289
 -0.7224 0.9125 0.1900 2.1676
0.017167
0.96442
MDA-MB-134-VI Taxol
Chemo
Chemotherapy
0.00012515
 -0.7183 1.3004 0.3511 0.5352
0.00075273
0.89205
HCC1500 Doxorubicin
Chemo
Chemotherapy
0.016258
 -0.7134 0.7518 0.1833 0.7212
0.058468
0.98572
PDX1328 Dinaciclib
pan CDK
Cell cycle
0.011496
 -0.7107 0.7519 0.2292 3.5560
0.014708
0.9982
MDA-MB-468 Cediranib
VEGFR/cKIT
RTK
3.9154
 -0.7083 0.1649 0.0970 3.0423
5.6183
0.9962
PDXHCI002 Topotecan
Topo I
Chemotherapy
0.0066461
 -0.7006 1.0199 0.1157 0.8130
0.015555
0.94766
HCC70 AZD7762
CHK1/2
Cell cycle
0.040563
 -0.7002 0.8995 0.3250 2.5054
0.056277
0.99456
CAMA-1 Ceritinib
ALK
RTK
1.797
 -0.6988 0.2366 0.0972 1.5849
3.5941
0.99647
BT-20 Dinaciclib
pan CDK
Cell cycle
0.018482
 -0.6979 0.6791 0.3193 3.4864
0.02362
0.99822
MDA-MB-436 Ceritinib
ALK
RTK
0.49893
 -0.6974 0.4169 0.1006 0.9667
1.4927
0.99602
HCC1395 AZD7762
CHK1/2
Cell cycle
0.02128
 -0.6899 0.8845 0.2607 2.2723
0.028104
0.96763
MDA-MB-453 Cediranib
VEGFR/cKIT
RTK
2.7824
 -0.6894 0.1569 0.0768 3.0858
3.7659
0.99464
MDA-MB-453 Ceritinib
ALK
RTK
0.36617
 -0.6866 0.4840 0.1577 1.1705
0.84209
0.99139
HCC70 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.15092
 -0.6846 0.5796 0.1546 0.7043
0.64661
0.98584
PDX1258 Ceritinib
ALK
RTK
2.081
 -0.6841 0.2165 0.0876 1.5671
4.1949
0.9759
HCC70 Cisplatin
Chemo
Chemotherapy
1.3073
 -0.6832 0.2650 0.0820 1.3165
3.0116
0.99076
MDA-MB-134-VI Tivantinib
MET
RTK
0.15045
 -0.6776 0.6505 0.1737 2.2582
0.21541
0.99657
PDXHCI002 Abemaciclib
CDK4/6
Cell cycle
0.047944
 -0.6767 0.7662 0.1664 0.6873
0.18848
0.98885
MDA-MB-361 AZD7762
CHK1/2
Cell cycle
0.0076402
 -0.6753 1.0533 0.2116 2.0458
0.010426
0.97675
HCC1428 Dinaciclib
pan CDK
Cell cycle
0.017078
 -0.6716 0.6610 0.2408 2.9825
0.02239
0.9979