Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1143 Volasertib
PLK
Cell cycle
0.0045882
 -0.3453 0.7290 0.2418 1.8336
0.005996
0.99928
Hs 578T Buparlisib
pan PI3K
PI3K/mTOR
0.68631
 -0.3434 0.3760 0.1520 1.4596
1.0562
0.9918
MDA-MB-361 Abemaciclib
CDK4/6
Cell cycle
0.0053492
 -0.3418 0.8279 0.0335 0.5371
0.0096902
0.8686
SK-BR-3 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0036122
 -0.3416 0.7338 0.1751 1.3620
0.0050857
0.99744
HCC1954 Alpelisib
PI3Ka
PI3K/mTOR
1.2292
 -0.3408 0.2652 0.1073 0.8509
4.4679
0.99224
SK-BR-3 Taxol
Chemo
Chemotherapy
0.0019068
 -0.3401 0.8905 0.3665 2.3888
0.0023578
0.96349
HME1 Topotecan
Topo I
Chemotherapy
0.0072669
 -0.3399 0.8727 0.2534 1.2621
0.0091245
0.95352
MDA-MB-468 Doxorubicin
Chemo
Chemotherapy
0.0054214
 -0.3392 0.9121 0.3191 2.4137
0.0067542
0.99424
CAL-51 Luminespib
HSP90
Misc
0.0063934
 -0.3386 0.7043 0.2784 3.0050
0.0075437
0.9995
HCC1954 Doxorubicin
Chemo
Chemotherapy
0.0071835
 -0.3378 0.7296 0.2544 1.4590
0.0086345
0.96869
CAL-51 Volasertib
PLK
Cell cycle
0.0059136
 -0.3372 0.6787 0.2411 3.0715
0.0068268
0.99697
HCC1395 Dasatinib
BCR/ABL
MAPK/nRTK
0.074545
 -0.3369 0.6018 0.0918 1.9595
0.089698
0.98974
PDX1328 Dasatinib
BCR/ABL
MAPK/nRTK
0.035818
 -0.3368 0.6929 0.0612 0.7466
0.064434
0.94799
BT-20 Cisplatin
Chemo
Chemotherapy
0.79098
 -0.3367 0.3338 0.0794 0.9579
1.7289
0.98666
CAL-120 Topotecan
Topo I
Chemotherapy
0.007493
 -0.3364 0.9130 0.2556 1.1649
0.010414
0.97973
SUM149PT Buparlisib
pan PI3K
PI3K/mTOR
1.4121
 -0.3357 0.2539 0.1216 1.9093
1.9133
0.99941
HCC1143 Taxol
Chemo
Chemotherapy
0.0020688
 -0.3349 0.8388 0.3074 2.5955
0.0024565
0.99279
HME1 Luminespib
HSP90
Misc
0.0085459
 -0.3346 0.6544 0.3132 5.0000
0.0094546
0.99721
HCC38 AZD7762
CHK1/2
Cell cycle
0.0094764
 -0.3341 0.9185 0.2951 2.0434
0.01177
0.98869
MDA-MB-436 Abemaciclib
CDK4/6
Cell cycle
2.1015
 -0.3331 0.1897 0.0464 1.1593
5.3251
0.99054
MDA-MB-231 Ceritinib
ALK
RTK
0.86565
 -0.3326 0.3444 0.1014 1.9065
1.1609
0.99581
SUM1315MO2 Topotecan
Topo I
Chemotherapy
0.011771
 -0.3317 0.7690 0.2174 0.3263
0.11949
0.94357
BT-549 Doxorubicin
Chemo
Chemotherapy
0.006482
 -0.3312 0.7603 0.1972 1.5744
0.0079126
0.9824
PDX1258 Abemaciclib
CDK4/6
Cell cycle
0.67289
 -0.3305 0.3350 0.0542 1.0569
1.2734
0.99626
HCC1500 Tivantinib
MET
RTK
0.11523
 -0.3304 0.5109 0.1445 1.9906
0.13024
0.97326