Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

 Full screen view
Filter results: >>>>
Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MCF 10A Pictilisib
pan PI3K
PI3K/mTOR
1.8745
 0.1934 0.2623 -0.0025 0.4160
26.2875
0.97592
MDA-MB-134-VI ABT-737
Bcl2/XL
Misc
1.7727
 -0.8735 0.2629 0.1112 1.9770
3.09
0.99496
HCC1937 Buparlisib
pan PI3K
PI3K/mTOR
1.4479
 -0.2256 0.2634 0.0691 1.0878
2.8639
0.99474
HCC70 Cisplatin
Chemo
Chemotherapy
1.3073
 -0.6832 0.2650 0.0820 1.3165
3.0116
0.99076
HCC1954 Alpelisib
PI3Ka
PI3K/mTOR
1.2292
 -0.3408 0.2652 0.1073 0.8509
4.4679
0.99224
HCC1428 Cisplatin
Chemo
Chemotherapy
0.91164
 0.1223 0.2655 0.0096 1.2004
0.80529
0.9803
HCC70 Cabozantinib
VEGFR2/MET
RTK
1.5024
 -0.0911 0.2658 0.0226 0.5892
9.6961
0.92355
MDA-MB-157 Abemaciclib
CDK4/6
Cell cycle
1.7983
 -0.6042 0.2687 0.0667 1.1925
4.518
0.93286
MDA-MB-231 Saracatinib
SRC
MAPK/nRTK
2.3337
 0.2801 0.2687 0.0262 0.3311
64.4143
0.98467
SUM159PT AZD7762
CHK1/2
Cell cycle
0.81589
 -0.1124 0.2697 0.0926 1.5031
0.93462
0.99443
PDXHCI002 Bleomycin
Radiation
Misc
1.1636
 -0.1199 0.2715 -0.0373 0.9659
2.0671
0.9892
Hs 578T Vorinostat
HDAC
Misc
0.90288
 -0.1689 0.2728 0.1049 2.2431
1.0225
0.99568
MDA-MB-134-VI Bleomycin
Radiation
Misc
1.7911
 0.0193 0.2734 0.0108 0.5040
15.841
0.87961
CAMA-1 Bleomycin
Radiation
Misc
1.6866
 -0.0365 0.2741 0.0341 0.6542
9.0438
0.951
T47D Neratinib
EGFR/HER2
RTK
0.42314
 0.1949 0.2741 0.0059 0.4966
0.81232
0.9874
HCC1954 Cisplatin
Chemo
Chemotherapy
1.2467
 -0.0741 0.2747 0.0807 1.1281
1.7233
0.97383
MDA-MB-231 Buparlisib
pan PI3K
PI3K/mTOR
1.5103
 -0.2351 0.2751 0.0596 1.9855
1.8969
0.98328
HCC1419 Saracatinib
SRC
MAPK/nRTK
0.91888
 -0.1146 0.2758 0.0128 0.8021
1.8388
0.98394
MCF7 Trametinib
MEK
MAPK/nRTK
Inf
 0.5581 0.2767 0.0114 1.2083
0.0027903
0.99413
PDX1258 Saracatinib
SRC
MAPK/nRTK
0.7252
 0.1837 0.2770 0.0370 0.8198
0.50742
0.98008
HCC1937 Taselisib
PI3Ka, g, d
PI3K/mTOR
1.2267
 0.1206 0.2771 0.0422 0.5159
3.7186
0.99159
HME1 Neratinib
EGFR/HER2
RTK
0.15243
 0.0983 0.2773 0.0166 1.3397
0.11637
0.9808
PDX1258 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.99608
 0.1062 0.2777 0.0362 0.6747
1.3027
0.98871
PDXHCI002 Palbociclib
CDK4/6
Cell cycle
0.12955
 0.2766 0.2793 -0.0122 1.1851
0.053617
0.97783
HCC1395 Ipatasertib
AKT
PI3K/mTOR
0.93351
 0.1903 0.2795 0.0199 0.6198
0.7738
0.97632