Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC70 Cediranib
VEGFR/cKIT
RTK
4.5386
 -0.3262 0.0890 0.0440 2.2440
7.4053
0.99062
MDA-MB-231 Alpelisib
PI3Ka
PI3K/mTOR
48.2918
 0.6904 0.0895 0.0045 0.4504
553.5356
0.61498
HME1 ABT-737
Bcl2/XL
Misc
Inf
 0.4949 0.0896 0.0303 5.0000
1.1036
0.96879
Hs 578T Alpelisib
PI3Ka
PI3K/mTOR
11.8954
 0.5308 0.0905 0.0063 0.7199
54.7171
0.9693
CAL-51 Neratinib
EGFR/HER2
RTK
2.2484
 0.2802 0.0910 0.0109 1.5163
4.6402
0.98601
MDA-MB-436 PF-4708671
p70S6K
PI3K/mTOR
4.7528
 0.1938 0.0918 0.0048 1.3212
6.5976
0.98815
CAL-120 Alpelisib
PI3Ka
PI3K/mTOR
21.5328
 0.6075 0.0922 -0.0015 0.5034
190.956
0.93579
HCC1143 Olaparib
PARP
Misc
8.8262
 0.4562 0.0925 0.0158 0.7545
37.8573
0.98047
MDA-MB-453 Cisplatin
Chemo
Chemotherapy
3.4106
 0.1328 0.0938 -0.0013 3.0256
3.151
0.9887
HCC1395 TGX221
PI3Kb
PI3K/mTOR
8.4625
 0.4581 0.0950 0.0125 0.6815
16.0341
0.94431
MCF 10A Cisplatin
Chemo
Chemotherapy
4.2937
 0.3794 0.0952 0.0149 2.1287
2.4561
0.99519
HCC1806 Olaparib
PARP
Misc
10.3367
 0.4886 0.0953 0.0224 0.7744
42.7088
0.92848
SUM1315MO2 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.5951 0.0977 0.0059 0.9518
1.3643
0.93531
MDA-MB-134-VI Cediranib
VEGFR/cKIT
RTK
4.2103
 -0.9999 0.0977 0.0979 5.0000
5.2449
0.99321
SK-BR-3 Cisplatin
Chemo
Chemotherapy
5.1075
 0.2490 0.0978 0.0114 1.4151
5.7965
0.99044
HCC1500 Olaparib
PARP
Misc
6.3506
 0.2744 0.0985 0.0084 1.0887
17.4212
0.94589
SUM1315MO2 ABT-737
Bcl2/XL
Misc
5.9406
 0.3056 0.0987 0.0360 0.8016
23.3924
0.93756
Hs 578T Olaparib
PARP
Misc
8.9082
 0.4435 0.0997 0.0101 1.0369
25.6993
0.93656
HCC38 Saracatinib
SRC
MAPK/nRTK
29.3313
 0.6139 0.1013 0.0162 0.4862
24.1837
0.94737
HCC38 Neratinib
EGFR/HER2
RTK
3.1556
 0.4571 0.1019 0.0168 0.7043
15.0154
0.87632
HME1 Cabozantinib
VEGFR2/MET
RTK
3.2402
 -0.1052 0.1020 0.0260 2.6885
3.6278
0.98973
MDA-MB-436 Dasatinib
BCR/ABL
MAPK/nRTK
Inf
 0.6528 0.1022 0.0098 0.0000
Inf
0.40773
HCC1143 Cabozantinib
VEGFR2/MET
RTK
10.6105
 0.5122 0.1025 0.0156 0.9383
34.2157
0.84631
HCC1143 ABT-737
Bcl2/XL
Misc
6.1992
 0.3758 0.1027 0.0110 0.8672
8.5825
0.98522
MDA-MB-468 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.7230 0.1032 0.0343 0.5264
0.7426
0.94963