Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1328 Pictilisib
pan PI3K
PI3K/mTOR
0.2981
 -0.2326 0.4385 0.0405 0.5373
1.3322
0.97906
BT-20 Etoposide
Topo II
Chemotherapy
0.30148
 -0.3834 0.4591 0.1362 1.2176
0.48057
0.99643
HCC1954 Abemaciclib
CDK4/6
Cell cycle
0.30182
 -0.5049 0.4578 0.0869 0.4867
2.8851
0.937
MDA-MB-468 Tivantinib
MET
RTK
0.30706
 -0.4549 0.4903 0.2341 2.9835
0.37002
0.99499
HCC38 Tivantinib
MET
RTK
0.30919
 -0.2702 0.4367 0.1297 1.8013
0.39141
0.99767
PDX1328 Alpelisib
PI3Ka
PI3K/mTOR
0.31193
 -0.0050 0.3735 0.0319 0.8438
0.32361
0.95669
MDA-MB-361 Ipatasertib
AKT
PI3K/mTOR
0.31325
 -0.5798 0.4548 0.0905 0.7404
1.2042
0.98932
PDX1258 Etoposide
Topo II
Chemotherapy
0.31701
 -0.1807 0.3942 0.1360 1.0906
0.41876
0.99346
HCC70 Tivantinib
MET
RTK
0.3335
 -0.5657 0.4968 0.1515 2.0000
0.48673
0.99617
HCC38 Etoposide
Topo II
Chemotherapy
0.33384
 -0.4242 0.4494 0.1891 1.4384
0.50554
0.99763
Hs 578T Tivantinib
MET
RTK
0.33668
 -0.3204 0.4411 0.2071 2.0560
0.42597
0.99878
PDXHCI002 Ceritinib
ALK
RTK
0.33749
 -0.6341 0.5101 0.1873 1.5133
0.59866
0.99609
MCF 10A Abemaciclib
CDK4/6
Cell cycle
0.34027
 0.1513 0.3811 -0.0012 0.5714
0.28176
0.99756
CAMA-1 Ipatasertib
AKT
PI3K/mTOR
0.34089
 -0.2361 0.4116 0.0837 0.7950
0.66403
0.98884
MDA-MB-361 Tivantinib
MET
RTK
0.34234
 -0.6060 0.5161 0.1344 1.7286
0.54407
0.99764
CAL-85-1 Buparlisib
pan PI3K
PI3K/mTOR
0.34255
 -0.3199 0.4420 0.1137 0.9213
0.69609
0.99686
MCF7 Ceritinib
ALK
RTK
0.34376
 -0.6157 0.4566 0.1487 0.9502
0.88109
0.9932
T47D Tivantinib
MET
RTK
0.3478
 -0.1544 0.3824 0.1267 3.7033
0.37139
0.99567
HCC1937 Etoposide
Topo II
Chemotherapy
0.35445
 -0.1182 0.3932 0.1412 0.8265
0.49943
0.98817
HCC70 Etoposide
Topo II
Chemotherapy
0.36498
 -0.1518 0.4535 0.0513 2.1004
0.41879
0.96872
MDA-MB-453 Ceritinib
ALK
RTK
0.36617
 -0.6866 0.4840 0.1577 1.1705
0.84209
0.99139
MDA-MB-436 Tivantinib
MET
RTK
0.3675
 -0.2711 0.4215 0.0897 2.2220
0.44342
0.99833
SUM1315MO2 Tivantinib
MET
RTK
0.36967
 -0.4300 0.4751 0.1718 2.1700
0.49553
0.9978
CAL-51 Palbociclib
CDK4/6
Cell cycle
0.37241
 0.3607 0.2498 -0.0215 0.8353
0.084749
0.99265
SUM159PT Tivantinib
MET
RTK
0.37997
 -0.1921 0.3954 0.1806 2.0717
0.4458
0.9982