Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
CAMA-1 Dinaciclib
pan CDK
Cell cycle
0.014558
 -0.4849 0.6062 0.1927 2.0283
0.019954
0.99839
HCC70 Dasatinib
BCR/ABL
MAPK/nRTK
0.0096376
 -0.5787 1.0609 0.1267 1.0559
0.020015
0.98982
HME1 INK-128
mTORC1/2
PI3K/mTOR
0.033475
 0.1969 0.4005 0.0164 1.3589
0.020278
0.99162
CAMA-1 Doxorubicin
Chemo
Chemotherapy
0.0074655
 -0.6517 0.8426 0.2593 0.7583
0.020458
0.96039
HCC1143 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.9185 0.0347 0.0040 4.9981
0.020639
0.76284
MDA-MB-468 INK-128
mTORC1/2
PI3K/mTOR
0.023529
 0.0573 0.5025 0.1038 1.2151
0.020647
0.99651
PDX1328 Palbociclib
CDK4/6
Cell cycle
0.028878
 0.1110 0.4289 -0.0020 1.3039
0.020889
0.9674
T47D Dinaciclib
pan CDK
Cell cycle
0.019853
 -0.2109 0.4815 0.0484 5.0000
0.021113
0.99494
HCC1806 Doxorubicin
Chemo
Chemotherapy
0.015898
 -0.3241 0.6281 0.1971 1.0948
0.021206
0.97525
PDX1258 AZD7762
CHK1/2
Cell cycle
0.014946
 -0.4528 0.9199 0.3234 1.6838
0.021221
0.99249
MDA-MB-436 Trametinib
MEK
MAPK/nRTK
Inf
 0.5572 0.1820 0.0015 1.0351
0.021252
0.93697
PDX1328 Doxorubicin
Chemo
Chemotherapy
0.013267
 -0.7789 0.8023 0.1468 1.4934
0.021574
0.96338
HCC1500 Topotecan
Topo I
Chemotherapy
0.0054632
 -0.8011 1.2171 0.1857 0.7137
0.022012
0.99509
HCC1428 Topotecan
Topo I
Chemotherapy
0.010613
 -0.3764 0.8345 0.1405 0.6324
0.02202
0.8529
HCC1500 ABT-737
Bcl2/XL
Misc
0.0085142
 -0.7359 1.1288 0.3716 0.9283
0.022222
0.99554
CAL-85-1 Topotecan
Topo I
Chemotherapy
0.015768
 -0.2957 0.8426 0.2732 1.2311
0.02233
0.99293
T47D Palbociclib
CDK4/6
Cell cycle
0.027507
 0.1166 0.4501 0.0077 1.5536
0.022367
0.99262
HCC1428 Dinaciclib
pan CDK
Cell cycle
0.017078
 -0.6716 0.6610 0.2408 2.9825
0.02239
0.9979
SUM159PT Doxorubicin
Chemo
Chemotherapy
0.019121
 -0.2740 0.6068 0.2965 1.5857
0.022541
0.98806
SUM1315MO2 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.015037
 -0.0903 0.4863 0.0621 0.7079
0.022637
0.99665
HCC1419 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0091784
 -0.4046 0.8523 0.0945 0.5809
0.022714
0.98223
MDA-MB-468 Topotecan
Topo I
Chemotherapy
0.015779
 -0.6577 1.0692 0.4464 2.1036
0.023029
0.99528
MDA-MB-157 Dinaciclib
pan CDK
Cell cycle
0.017724
 -0.9106 0.7675 0.3195 3.8857
0.023072
0.99901
HCC1395 Trametinib
MEK
MAPK/nRTK
0.17156
 0.4498 0.1903 0.0218 1.7439
0.023111
0.97973
MCF 10A Volasertib
PLK
Cell cycle
0.022128
 -0.0887 0.4466 0.1711 3.5358
0.023168
0.99997