Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SUM149PT Dinaciclib
pan CDK
Cell cycle
0.013311
 -0.5676 0.6891 0.3611 4.0226
0.016068
0.99946
HCC1806 Dinaciclib
pan CDK
Cell cycle
0.013395
 -0.4585 0.6439 0.3114 3.4710
0.016174
0.99891
SUM1315MO2 Doxorubicin
Chemo
Chemotherapy
0.018222
 -0.0635 0.5132 0.1324 2.0980
0.016338
0.96491
SUM1315MO2 Trametinib
MEK
MAPK/nRTK
0.021115
 0.1329 0.3887 0.0532 1.0540
0.01638
0.99458
HCC1143 Dinaciclib
pan CDK
Cell cycle
0.015148
 -0.2527 0.5451 0.1106 5.0000
0.016398
0.9989
SK-BR-3 Abemaciclib
CDK4/6
Cell cycle
0.035311
 0.1432 0.5363 0.0387 0.6381
0.016543
0.96857
MDA-MB-361 Palbociclib
CDK4/6
Cell cycle
0.019625
 0.1481 0.4822 0.0065 2.1670
0.01672
0.99444
CAL-51 Dinaciclib
pan CDK
Cell cycle
0.014709
 -0.3585 0.5985 0.2374 3.5319
0.017105
0.99939
MDA-MB-361 Topotecan
Topo I
Chemotherapy
0.011361
 -0.7622 1.1276 0.2239 1.9673
0.01715
0.98983
MDA-MB-361 Doxorubicin
Chemo
Chemotherapy
0.012289
 -0.7224 0.9125 0.1900 2.1676
0.017167
0.96442
SUM159PT Dinaciclib
pan CDK
Cell cycle
0.016967
 -0.0646 0.4536 0.1030 5.0000
0.017277
0.99948
HME1 Volasertib
PLK
Cell cycle
0.017242
 -0.0817 0.4263 0.1273 3.6204
0.017483
0.99425
MCF 10A Dinaciclib
pan CDK
Cell cycle
0.016244
 -0.2300 0.5279 0.2344 5.0000
0.017523
0.99904
MCF 10A INK-128
mTORC1/2
PI3K/mTOR
0.024199
 0.1716 0.4673 -0.0027 1.3149
0.017581
0.99992
HCC38 INK-128
mTORC1/2
PI3K/mTOR
0.01911
 -0.0087 0.5361 0.0402 1.3664
0.018127
0.99621
HCC1419 Volasertib
PLK
Cell cycle
0.020718
 0.0685 0.3636 0.0462 1.8241
0.018178
0.98538
HCC1954 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0096629
 -0.3280 0.5536 0.1704 0.7380
0.018218
0.98125
HCC1428 Volasertib
PLK
Cell cycle
0.018634
 -0.0388 0.4063 0.0917 2.1456
0.018507
0.99276
MDA-MB-468 Dinaciclib
pan CDK
Cell cycle
0.015576
 -0.4131 0.5681 0.1843 2.8840
0.018635
0.99641
HCC1500 Dinaciclib
pan CDK
Cell cycle
0.013792
 -0.5720 0.6616 0.1978 2.3762
0.018927
0.99749
HME1 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.025621
 0.0764 0.3468 0.0310 1.0824
0.018946
0.97645
SK-BR-3 Topotecan
Topo I
Chemotherapy
0.016549
 -0.2711 0.7941 0.1919 1.9350
0.01923
0.98214
SUM159PT Taselisib
PI3Ka, g, d
PI3K/mTOR
0.024971
 0.0916 0.5859 0.0023 1.1458
0.019444
0.99527
Hs 578T AZD7762
CHK1/2
Cell cycle
0.015096
 -0.5983 0.8646 0.4133 1.8783
0.01967
0.95944
HCC1806 INK-128
mTORC1/2
PI3K/mTOR
0.052338
 0.2620 0.3895 0.0353 0.9021
0.019916
0.9778