Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDX1258 Vorinostat
HDAC
Misc
1.5746
 -0.0232 0.2113 0.0249 1.3725
1.8225
0.99287
MDA-MB-231 Vorinostat
HDAC
Misc
1.2388
 -0.3848 0.2821 0.1116 1.7685
1.7699
0.99365
BT-20 Vorinostat
HDAC
Misc
2.217
 -0.1134 0.1610 0.0705 1.6271
2.8626
0.99345
HCC1806 Vorinostat
HDAC
Misc
1.1276
 0.0178 0.2397 0.0491 1.3263
1.2167
0.99564
MCF 10A Vorinostat
HDAC
Misc
2.5293
 0.0566 0.1675 0.0065 1.2709
3.1489
0.99982
MDA-MB-361 Vorinostat
HDAC
Misc
0.76224
 -0.9392 0.4607 0.1761 2.2187
1.2401
0.99784
MDA-MB-453 Vorinostat
HDAC
Misc
0.9215
 -0.6076 0.3291 0.1421 3.3225
1.1628
0.99512
HCC1954 Vorinostat
HDAC
Misc
1.426
 -0.1401 0.2339 0.0833 1.2390
2.0871
0.99732
HCC70 Vorinostat
HDAC
Misc
0.40578
 -0.4765 0.4082 0.0748 0.8914
1.0253
0.99218
MDA-MB-134-VI Vorinostat
HDAC
Misc
2.4577
 -0.5014 0.1748 0.0365 5.0000
2.8258
0.99386
HCC1954 Volasertib
PLK
Cell cycle
0.0065835
 -0.1540 0.6139 0.2792 3.4968
0.0071308
0.99812
PDX1328 Volasertib
PLK
Cell cycle
0.0025124
 -0.5731 0.9694 0.2182 2.8453
0.0032751
0.99856
MDA-MB-231 Volasertib
PLK
Cell cycle
0.0043583
 -0.0186 0.5873 0.1359 3.6103
0.0044117
0.99795
HCC1937 Volasertib
PLK
Cell cycle
0.011931
 -0.1480 0.4968 0.1111 1.6595
0.013417
0.99404
CAL-120 Volasertib
PLK
Cell cycle
0.0018536
 0.0258 0.6758 0.2649 2.5191
0.001844
0.99276
HCC1500 Volasertib
PLK
Cell cycle
0.011592
 0.2861 0.3454 0.0484 5.0000
0.0099361
0.97732
HCC70 Volasertib
PLK
Cell cycle
0.0065224
 -0.2049 0.6421 0.1395 3.2698
0.0072379
0.9841
MDA-MB-436 Volasertib
PLK
Cell cycle
0.0051788
 -0.1792 0.6616 0.1034 3.6059
0.0056092
0.99947
BT-549 Volasertib
PLK
Cell cycle
0.0088352
 -0.2289 0.5676 0.1490 2.4967
0.0098732
0.99586
HCC1395 Volasertib
PLK
Cell cycle
0.0032085
 -0.2962 0.7641 0.1714 2.7096
0.00378
0.99662
MDA-MB-361 Volasertib
PLK
Cell cycle
0.0035439
 -0.4972 0.8204 0.1921 4.6311
0.0040451
0.98886
CAL-51 Volasertib
PLK
Cell cycle
0.0059136
 -0.3372 0.6787 0.2411 3.0715
0.0068268
0.99697
PDX1258 Volasertib
PLK
Cell cycle
0.0073734
 -0.2320 0.5602 0.1765 1.8198
0.0083258
0.98847
MDA-MB-468 Volasertib
PLK
Cell cycle
0.002104
 -0.4485 0.9279 0.3934 2.9173
0.0026072
0.99938
MCF7 Volasertib
PLK
Cell cycle
0.0028671
 -0.0338 0.6070 0.1245 4.2176
0.002824
0.99423