Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9185 | 0.0347 | 0.0040 | 4.9981 | 0.020639 | 0.76284 |
| T47D | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7986 | -0.0066 | -0.0002 | 2.2233 | 4.3807 | 0.7868 |
| SUM1315MO2 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7054 | 0.1362 | 0.0073 | 0.9367 | 0.077385 | 0.83645 |
| HCC1419 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7941 | -0.0049 | 0.0002 | 5.0000 | 3.889 | 0.79312 |
| PDX1258 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9970 | -0.0328 | 0.0026 | 0.0000 | Inf | -2.2747 |
| HCC70 | TGX221 | PI3Kb | PI3K/mTOR | 0.092754 | 0.0049 | 0.4729 | 0.0591 | 0.8818 | 0.076452 | 0.9787 |
| MDA-MB-453 | TGX221 | PI3Kb | PI3K/mTOR | 15.3342 | 0.8281 | -0.0281 | 0.0177 | 4.9457 | 12.4514 | 0.62788 |
| HCC1937 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8377 | 0.0202 | 0.0070 | 0.6226 | 52.0493 | 0.74303 |
| MDA-MB-468 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7230 | 0.1032 | 0.0343 | 0.5264 | 0.7426 | 0.94963 |
| HCC1500 | TGX221 | PI3Kb | PI3K/mTOR | 10.1303 | 0.5035 | 0.0860 | 0.0066 | 0.8370 | 24.4491 | 0.82467 |
| SK-BR-3 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7496 | -0.0084 | 0.0076 | 4.9846 | 4.3561 | 0.86723 |
| MDA-MB-436 | TGX221 | PI3Kb | PI3K/mTOR | 22.0461 | 0.7221 | 0.0019 | 0.0048 | 1.3022 | 18.6589 | 0.84405 |
| CAL-120 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0198 | -0.0168 | -0.0059 | 0.0000 | Inf | -0.45144 |
| HCC1806 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9819 | -0.0154 | 0.0035 | 0.0000 | Inf | -0.19348 |
| MCF 10A | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9505 | 0.0050 | 0.0003 | 0.8181 | 270.4333 | 0.86411 |
| SUM149PT | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0138 | -0.0216 | 0.0006 | 0.0000 | Inf | -4.4171 |
| MDA-MB-134-VI | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8589 | -0.0381 | -0.0029 | 0.0000 | Inf | 0.38211 |
| HCC38 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9515 | -0.0246 | 0.0013 | 0.0000 | Inf | -0.17011 |
| CAL-51 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9105 | -0.0094 | 0.0003 | 0.0000 | Inf | 0.56048 |
| CAL-85-1 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9895 | -0.0309 | 0.0002 | 0.0000 | Inf | -1.0218 |
| MDA-MB-231 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.8508 | 0.0154 | 0.0050 | 0.6946 | 20.4646 | 0.68698 |
| PDX1328 | TGX221 | PI3Kb | PI3K/mTOR | 22.8162 | 0.7594 | 0.0116 | 0.0024 | 1.1153 | 60.9221 | 0.6986 |
| HME1 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0265 | -0.0318 | -0.0005 | 0.0000 | Inf | -0.12868 |
| HCC1428 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7695 | 0.0143 | 0.0033 | 4.9999 | 3.7973 | 0.75865 |
| CAMA-1 | TGX221 | PI3Kb | PI3K/mTOR | 42.7345 | 0.8500 | 0.0067 | 0.0034 | 0.9968 | 118.889 | 0.79474 |