Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SUM159PT Volasertib
PLK
Cell cycle
0.024832
 0.0468 0.3873 0.1208 3.5660
0.024055
0.99966
CAL-85-1 Luminespib
HSP90
Misc
0.006517
 -0.3836 0.7497 0.3002 4.8089
0.0073269
0.99963
SUM159PT Vorinostat
HDAC
Misc
1.9985
 0.1195 0.1810 0.0216 1.3229
1.9352
0.99956
SUM149PT Luminespib
HSP90
Misc
0.005116
 -0.3912 0.7555 0.3563 2.6742
0.0063272
0.99952
MDA-MB-361 Luminespib
HSP90
Misc
0.0071417
 -0.8855 0.9781 0.3455 4.9987
0.0087421
0.9995
MCF7 Dinaciclib
pan CDK
Cell cycle
0.0083068
 -0.2493 0.6441 0.1256 3.5461
0.009348
0.9995
CAL-51 Luminespib
HSP90
Misc
0.0063934
 -0.3386 0.7043 0.2784 3.0050
0.0075437
0.9995
SUM159PT Dinaciclib
pan CDK
Cell cycle
0.016967
 -0.0646 0.4536 0.1030 5.0000
0.017277
0.99948
MDA-MB-436 Volasertib
PLK
Cell cycle
0.0051788
 -0.1792 0.6616 0.1034 3.6059
0.0056092
0.99947
CAL-120 Dinaciclib
pan CDK
Cell cycle
0.009892
 -0.1320 0.5549 0.1203 4.4157
0.010404
0.99947
SUM149PT Dinaciclib
pan CDK
Cell cycle
0.013311
 -0.5676 0.6891 0.3611 4.0226
0.016068
0.99946
CAL-51 Tivantinib
MET
RTK
0.58755
 -0.2821 0.3592 0.1039 1.5478
0.80088
0.99945
SUM149PT Buparlisib
pan PI3K
PI3K/mTOR
1.4121
 -0.3357 0.2539 0.1216 1.9093
1.9133
0.99941
CAL-51 Bleomycin
Radiation
Misc
0.1694
 -0.1344 0.4855 0.0479 0.8490
0.24736
0.9994
CAL-51 Dinaciclib
pan CDK
Cell cycle
0.014709
 -0.3585 0.5985 0.2374 3.5319
0.017105
0.99939
MDA-MB-468 Volasertib
PLK
Cell cycle
0.002104
 -0.4485 0.9279 0.3934 2.9173
0.0026072
0.99938
SUM159PT Neratinib
EGFR/HER2
RTK
1.0155
 0.3337 0.1585 0.0028 0.9807
0.58582
0.99938
SUM149PT Tivantinib
MET
RTK
0.27624
 -0.2313 0.4502 0.1850 2.3039
0.32281
0.99937
BT-549 INK-128
mTORC1/2
PI3K/mTOR
0.016573
 0.0717 0.5339 0.0484 1.5295
0.014683
0.99934
SUM159PT Saracatinib
SRC
MAPK/nRTK
13.9057
 0.5624 0.0724 -0.0011 0.9804
8.3037
0.99931
HCC1954 Trametinib
MEK
MAPK/nRTK
0.016729
 0.2287 0.4005 0.0565 0.8524
0.0082359
0.9993
SUM149PT Vorinostat
HDAC
Misc
1.3518
 -0.0716 0.2279 0.0446 1.5465
1.5699
0.9993
HCC1937 Luminespib
HSP90
Misc
0.011448
 -0.1867 0.5478 0.2244 4.8554
0.012181
0.99929
HCC1143 Volasertib
PLK
Cell cycle
0.0045882
 -0.3453 0.7290 0.2418 1.8336
0.005996
0.99928
SUM159PT Buparlisib
pan PI3K
PI3K/mTOR
1.5871
 -0.1942 0.2253 0.0613 1.5281
2.1811
0.99923