Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
BT-20 Taselisib
0.001
PI3Ka, g, d
PI3K/mTOR
 1.0187 0.00469
BT-20 Taselisib
0.0031623
PI3Ka, g, d
PI3K/mTOR
 0.8758 0.02377
BT-20 Taselisib
0.01
PI3Ka, g, d
PI3K/mTOR
 0.5767 0.04866
BT-20 Taselisib
0.031623
PI3Ka, g, d
PI3K/mTOR
 0.2994 0.10873
BT-20 Taselisib
0.1
PI3Ka, g, d
PI3K/mTOR
 0.1170 0.17172
BT-20 Taselisib
0.31623
PI3Ka, g, d
PI3K/mTOR
 0.0426 0.21670
BT-20 Taselisib
1.0
PI3Ka, g, d
PI3K/mTOR
 -0.0196 0.26438
BT-20 Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 -0.1041 0.36006
BT-20 Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 -0.3749 0.60583
BT-20 TGX221
0.001
PI3Kb
PI3K/mTOR
 1.0702 0.00236
BT-20 TGX221
0.0031623
PI3Kb
PI3K/mTOR
 1.0115 -0.00367
BT-20 TGX221
0.01
PI3Kb
PI3K/mTOR
 1.0640 0.00515
BT-20 TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.0404 0.00244
BT-20 TGX221
0.1
PI3Kb
PI3K/mTOR
 1.0903 -0.00716
BT-20 TGX221
0.31623
PI3Kb
PI3K/mTOR
 1.0870 -0.00445
BT-20 TGX221
1.0
PI3Kb
PI3K/mTOR
 1.1067 -0.00666
BT-20 TGX221
3.1623
PI3Kb
PI3K/mTOR
 1.0471 -0.01046
BT-20 TGX221
10.0
PI3Kb
PI3K/mTOR
 1.0152 -0.00843
BT-20 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0519 0.00274
BT-20 Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 1.0136 0.00054
BT-20 Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.9334 0.01136
BT-20 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.7223 0.02450
BT-20 Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.4196 0.08450
BT-20 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.1533 0.16173
BT-20 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.0795 0.17945