Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SK-BR-3 Dasatinib
0.31623
BCR/ABL
MAPK/nRTK
 1.1906 -0.00276
SK-BR-3 Dasatinib
1.0
BCR/ABL
MAPK/nRTK
 1.0781 0.00799
SK-BR-3 Dasatinib
3.1623
BCR/ABL
MAPK/nRTK
 0.6606 0.06194
SK-BR-3 Dasatinib
10.0
BCR/ABL
MAPK/nRTK
 0.0810 0.14318
SK-BR-3 Trametinib
0.0001
MEK
MAPK/nRTK
 0.9564 0.00881
SK-BR-3 Trametinib
0.00031623
MEK
MAPK/nRTK
 0.9711 0.00287
SK-BR-3 Trametinib
0.001
MEK
MAPK/nRTK
 0.9919 0.00810
SK-BR-3 Trametinib
0.0031623
MEK
MAPK/nRTK
 0.8740 0.01341
SK-BR-3 Trametinib
0.01
MEK
MAPK/nRTK
 0.8079 0.01615
SK-BR-3 Trametinib
0.031623
MEK
MAPK/nRTK
 0.7443 0.02287
SK-BR-3 Trametinib
0.1
MEK
MAPK/nRTK
 0.6342 0.02099
SK-BR-3 Trametinib
0.31623
MEK
MAPK/nRTK
 0.6828 0.02777
SK-BR-3 Trametinib
1.0
MEK
MAPK/nRTK
 0.7247 0.01778
SK-BR-3 Saracatinib
0.001
SRC
MAPK/nRTK
 1.0490 0.00803
SK-BR-3 Saracatinib
0.0031623
SRC
MAPK/nRTK
 1.0947 -0.00504
SK-BR-3 Saracatinib
0.01
SRC
MAPK/nRTK
 1.1099 -0.00667
SK-BR-3 Saracatinib
0.031623
SRC
MAPK/nRTK
 1.1799 -0.00899
SK-BR-3 Saracatinib
0.1
SRC
MAPK/nRTK
 1.1154 0.00279
SK-BR-3 Saracatinib
0.31623
SRC
MAPK/nRTK
 1.1562 -0.00826
SK-BR-3 Saracatinib
1.0
SRC
MAPK/nRTK
 1.0805 0.00131
SK-BR-3 Saracatinib
3.1623
SRC
MAPK/nRTK
 0.8591 0.01187
SK-BR-3 Saracatinib
10.0
SRC
MAPK/nRTK
 0.2786 0.09637
SK-BR-3 ABT-737
0.001
Bcl2/XL
Misc
 0.9095 0.00642
SK-BR-3 ABT-737
0.0031623
Bcl2/XL
Misc
 1.0399 0.00968
SK-BR-3 ABT-737
0.01
Bcl2/XL
Misc
 1.0744 0.00603