Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM159PT Neratinib
0.001
EGFR/HER2
RTK
 1.0094 0.00044
SUM159PT Neratinib
0.0031623
EGFR/HER2
RTK
 0.9962 -0.00023
SUM159PT Neratinib
0.01
EGFR/HER2
RTK
 0.9898 -0.00141
SUM159PT Neratinib
0.031623
EGFR/HER2
RTK
 0.9637 -0.00349
SUM159PT Neratinib
0.1
EGFR/HER2
RTK
 0.8778 -0.00196
SUM159PT Neratinib
0.31623
EGFR/HER2
RTK
 0.7165 0.00135
SUM159PT Neratinib
1.0
EGFR/HER2
RTK
 0.5077 0.00962
SUM159PT Neratinib
3.1623
EGFR/HER2
RTK
 0.3337 0.02401
SUM159PT Tivantinib
0.001
MET
RTK
 1.0001 0.00355
SUM159PT Tivantinib
0.0031623
MET
RTK
 1.0081 0.00135
SUM159PT Tivantinib
0.01
MET
RTK
 1.0165 0.00077
SUM159PT Tivantinib
0.031623
MET
RTK
 0.9992 0.00372
SUM159PT Tivantinib
0.1
MET
RTK
 1.0017 0.00527
SUM159PT Tivantinib
0.31623
MET
RTK
 0.5846 0.13926
SUM159PT Tivantinib
1.0
MET
RTK
 0.0134 0.41123
SUM159PT Tivantinib
3.1623
MET
RTK
 -0.1910 0.51047
SUM159PT Tivantinib
10.0
MET
RTK
 -0.1921 0.54983
SUM159PT Cediranib
0.001
VEGFR/cKIT
RTK
 1.0098 0.00023
SUM159PT Cediranib
0.0031623
VEGFR/cKIT
RTK
 1.0200 -0.00078
SUM159PT Cediranib
0.01
VEGFR/cKIT
RTK
 1.0195 0.00135
SUM159PT Cediranib
0.031623
VEGFR/cKIT
RTK
 0.9997 0.00150
SUM159PT Cediranib
0.1
VEGFR/cKIT
RTK
 0.9968 0.00269
SUM159PT Cediranib
0.31623
VEGFR/cKIT
RTK
 1.0048 -0.00107
SUM159PT Cediranib
1.0
VEGFR/cKIT
RTK
 0.9847 -0.00209
SUM159PT Cediranib
3.1623
VEGFR/cKIT
RTK
 0.9183 -0.00514