Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM159PT AZD7762
0.031623
CHK1/2
Cell cycle
 1.0283 -0.00024
SUM159PT AZD7762
0.1
CHK1/2
Cell cycle
 1.0022 0.01646
SUM159PT AZD7762
0.31623
CHK1/2
Cell cycle
 0.8229 0.05478
SUM159PT AZD7762
1.0
CHK1/2
Cell cycle
 0.3858 0.15068
SUM159PT AZD7762
3.1623
CHK1/2
Cell cycle
 0.0889 0.20237
SUM159PT AZD7762
10.0
CHK1/2
Cell cycle
 -0.1124 0.40902
SUM159PT Volasertib
0.0001
PLK
Cell cycle
 0.9934 0.00264
SUM159PT Volasertib
0.00031623
PLK
Cell cycle
 0.9872 0.00404
SUM159PT Volasertib
0.001
PLK
Cell cycle
 0.9908 0.00021
SUM159PT Volasertib
0.0031623
PLK
Cell cycle
 1.0137 0.00376
SUM159PT Volasertib
0.01
PLK
Cell cycle
 0.9608 0.00760
SUM159PT Volasertib
0.031623
PLK
Cell cycle
 0.3124 0.17514
SUM159PT Volasertib
0.1
PLK
Cell cycle
 0.0660 0.27087
SUM159PT Volasertib
0.31623
PLK
Cell cycle
 0.0468 0.31434
SUM159PT Volasertib
1.0
PLK
Cell cycle
 0.0542 0.30842
SUM159PT Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0072 -0.00082
SUM159PT Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0082 -0.00056
SUM159PT Dinaciclib
0.001
pan CDK
Cell cycle
 1.0105 0.00015
SUM159PT Dinaciclib
0.0031623
pan CDK
Cell cycle
 1.0177 0.00150
SUM159PT Dinaciclib
0.01
pan CDK
Cell cycle
 0.9397 0.00675
SUM159PT Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.0035 0.29018
SUM159PT Dinaciclib
0.1
pan CDK
Cell cycle
 -0.0289 0.18676
SUM159PT Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.0440 0.21795
SUM159PT Dinaciclib
1.0
pan CDK
Cell cycle
 -0.0646 0.22478
SUM159PT Cisplatin
0.0010833
Chemo
Chemotherapy
 1.0050 0.02090