Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM159PT Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 0.9963 -0.00253
SUM159PT Buparlisib
0.1
pan PI3K
PI3K/mTOR
 1.0017 -0.00187
SUM159PT Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.9105 -0.00430
SUM159PT Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.7058 -0.00009
SUM159PT Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 0.1570 0.09455
SUM159PT Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.1942 0.45888
SUM159PT Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.9957 0.00061
SUM159PT Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9930 -0.00213
SUM159PT Pictilisib
0.01
pan PI3K
PI3K/mTOR
 0.9847 -0.00285
SUM159PT Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.9822 -0.00455
SUM159PT Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.9298 -0.00468
SUM159PT Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.8144 -0.00692
SUM159PT Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.5262 -0.00713
SUM159PT Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.3124 -0.00003
SUM159PT Pictilisib
10.0
pan PI3K
PI3K/mTOR
 0.0942 0.00650
SUM159PT Ceritinib
0.001
ALK
RTK
 0.9891 0.00112
SUM159PT Ceritinib
0.0031623
ALK
RTK
 0.9902 0.00337
SUM159PT Ceritinib
0.01
ALK
RTK
 1.0080 -0.00023
SUM159PT Ceritinib
0.031623
ALK
RTK
 0.9871 -0.00104
SUM159PT Ceritinib
0.1
ALK
RTK
 0.9864 -0.00012
SUM159PT Ceritinib
0.31623
ALK
RTK
 0.9368 0.00183
SUM159PT Ceritinib
1.0
ALK
RTK
 0.7932 0.00327
SUM159PT Ceritinib
3.1623
ALK
RTK
 -0.0787 0.47423
SUM159PT Ceritinib
10.0
ALK
RTK
 -0.3800 0.80163
SUM159PT Neratinib
0.00031623
EGFR/HER2
RTK
 1.0083 -0.00349