Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF7 Trametinib
1.0
MEK
MAPK/nRTK
 0.5794 0.01371
MCF7 Saracatinib
0.001
SRC
MAPK/nRTK
 1.0135 0.00191
MCF7 Saracatinib
0.0031623
SRC
MAPK/nRTK
 0.9531 0.00403
MCF7 Saracatinib
0.01
SRC
MAPK/nRTK
 0.9086 0.00512
MCF7 Saracatinib
0.031623
SRC
MAPK/nRTK
 0.8515 0.01067
MCF7 Saracatinib
0.1
SRC
MAPK/nRTK
 0.6934 0.02285
MCF7 Saracatinib
0.31623
SRC
MAPK/nRTK
 0.6236 0.02546
MCF7 Saracatinib
1.0
SRC
MAPK/nRTK
 0.4015 0.04196
MCF7 Saracatinib
3.1623
SRC
MAPK/nRTK
 0.3461 0.04415
MCF7 Saracatinib
10.0
SRC
MAPK/nRTK
 0.2735 0.06039
MCF7 ABT-737
0.001
Bcl2/XL
Misc
 1.0368 0.00032
MCF7 ABT-737
0.0031623
Bcl2/XL
Misc
 1.0065 0.00132
MCF7 ABT-737
0.01
Bcl2/XL
Misc
 1.0485 0.00204
MCF7 ABT-737
0.031623
Bcl2/XL
Misc
 1.0232 0.00264
MCF7 ABT-737
0.1
Bcl2/XL
Misc
 1.0714 0.00352
MCF7 ABT-737
0.31623
Bcl2/XL
Misc
 1.0224 0.00654
MCF7 ABT-737
1.0
Bcl2/XL
Misc
 0.9311 0.01069
MCF7 ABT-737
3.1623
Bcl2/XL
Misc
 0.9198 0.01931
MCF7 ABT-737
10.0
Bcl2/XL
Misc
 0.7267 0.05756
MCF7 Vorinostat
0.001
HDAC
Misc
 0.9678 0.00091
MCF7 Vorinostat
0.0031623
HDAC
Misc
 0.9894 -0.00236
MCF7 Vorinostat
0.01
HDAC
Misc
 1.0061 -0.00306
MCF7 Vorinostat
0.031623
HDAC
Misc
 0.9936 0.00264
MCF7 Vorinostat
0.1
HDAC
Misc
 0.8717 0.00763
MCF7 Vorinostat
0.31623
HDAC
Misc
 0.6975 0.01978