Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
---|---|---|---|---|---|---|
SUM1315MO2 | Neratinib | 1.0 | EGFR/HER2 | RTK | 0.1748 | 0.08909 |
SUM1315MO2 | Neratinib | 3.1623 | EGFR/HER2 | RTK | 0.1140 | 0.08879 |
SUM1315MO2 | Tivantinib | 0.001 | MET | RTK | 1.0417 | 0.00389 |
SUM1315MO2 | Tivantinib | 0.0031623 | MET | RTK | 1.0192 | -0.00120 |
SUM1315MO2 | Tivantinib | 0.01 | MET | RTK | 1.0181 | 0.00453 |
SUM1315MO2 | Tivantinib | 0.031623 | MET | RTK | 0.9355 | 0.00282 |
SUM1315MO2 | Tivantinib | 0.1 | MET | RTK | 0.9251 | 0.03883 |
SUM1315MO2 | Tivantinib | 0.31623 | MET | RTK | 0.6152 | 0.11278 |
SUM1315MO2 | Tivantinib | 1.0 | MET | RTK | -0.1924 | 0.42530 |
SUM1315MO2 | Tivantinib | 3.1623 | MET | RTK | -0.4277 | 0.44873 |
SUM1315MO2 | Tivantinib | 10.0 | MET | RTK | -0.4300 | 0.51069 |
SUM1315MO2 | Cediranib | 0.001 | VEGFR/cKIT | RTK | 1.0030 | 0.00282 |
SUM1315MO2 | Cediranib | 0.0031623 | VEGFR/cKIT | RTK | 1.0254 | -0.00232 |
SUM1315MO2 | Cediranib | 0.01 | VEGFR/cKIT | RTK | 1.0347 | 0.00591 |
SUM1315MO2 | Cediranib | 0.031623 | VEGFR/cKIT | RTK | 0.9914 | 0.00424 |
SUM1315MO2 | Cediranib | 0.1 | VEGFR/cKIT | RTK | 0.9788 | 0.00298 |
SUM1315MO2 | Cediranib | 0.31623 | VEGFR/cKIT | RTK | 0.7669 | 0.01075 |
SUM1315MO2 | Cediranib | 1.0 | VEGFR/cKIT | RTK | 0.5716 | 0.02666 |
SUM1315MO2 | Cediranib | 3.1623 | VEGFR/cKIT | RTK | 0.2993 | 0.07623 |
SUM1315MO2 | Cediranib | 10.0 | VEGFR/cKIT | RTK | -0.2276 | 0.32283 |
SUM1315MO2 | Cabozantinib | 0.001 | VEGFR2/MET | RTK | 1.0236 | -0.00289 |
SUM1315MO2 | Cabozantinib | 0.0031623 | VEGFR2/MET | RTK | 1.0576 | 0.00449 |
SUM1315MO2 | Cabozantinib | 0.01 | VEGFR2/MET | RTK | 1.0048 | 0.00360 |
SUM1315MO2 | Cabozantinib | 0.031623 | VEGFR2/MET | RTK | 1.0767 | 0.00262 |
SUM1315MO2 | Cabozantinib | 0.1 | VEGFR2/MET | RTK | 0.9699 | 0.00994 |