Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| SUM1315MO2 | Volasertib | 0.0001 | PLK | Cell cycle | 0.9093 | 0.01247 |
| SUM1315MO2 | Volasertib | 0.00031623 | PLK | Cell cycle | 1.0623 | 0.00166 |
| SUM1315MO2 | Volasertib | 0.001 | PLK | Cell cycle | 0.9525 | 0.00450 |
| SUM1315MO2 | Volasertib | 0.0031623 | PLK | Cell cycle | 0.9729 | 0.00939 |
| SUM1315MO2 | Volasertib | 0.01 | PLK | Cell cycle | 0.4513 | 0.10657 |
| SUM1315MO2 | Volasertib | 0.031623 | PLK | Cell cycle | -0.2322 | 0.37882 |
| SUM1315MO2 | Volasertib | 0.1 | PLK | Cell cycle | -0.4082 | 0.51079 |
| SUM1315MO2 | Volasertib | 0.31623 | PLK | Cell cycle | -0.3877 | 0.52524 |
| SUM1315MO2 | Volasertib | 1.0 | PLK | Cell cycle | -0.3596 | 0.48717 |
| SUM1315MO2 | Dinaciclib | 0.0001 | pan CDK | Cell cycle | 1.1110 | 0.00021 |
| SUM1315MO2 | Dinaciclib | 0.00031623 | pan CDK | Cell cycle | 1.0028 | -0.00350 |
| SUM1315MO2 | Dinaciclib | 0.001 | pan CDK | Cell cycle | 1.0323 | 0.00457 |
| SUM1315MO2 | Dinaciclib | 0.0031623 | pan CDK | Cell cycle | 0.9193 | 0.00975 |
| SUM1315MO2 | Dinaciclib | 0.01 | pan CDK | Cell cycle | 0.6218 | 0.02693 |
| SUM1315MO2 | Dinaciclib | 0.031623 | pan CDK | Cell cycle | -0.6209 | 0.58097 |
| SUM1315MO2 | Dinaciclib | 0.1 | pan CDK | Cell cycle | -0.6422 | 0.63067 |
| SUM1315MO2 | Dinaciclib | 0.31623 | pan CDK | Cell cycle | -0.6615 | 0.63971 |
| SUM1315MO2 | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.6674 | 0.61233 |
| SUM1315MO2 | Cisplatin | 0.0010833 | Chemo | Chemotherapy | 1.0113 | -0.01160 |
| SUM1315MO2 | Cisplatin | 0.0033333 | Chemo | Chemotherapy | 0.9009 | 0.00959 |
| SUM1315MO2 | Cisplatin | 0.01 | Chemo | Chemotherapy | 0.8236 | -0.00666 |
| SUM1315MO2 | Cisplatin | 0.031667 | Chemo | Chemotherapy | 0.9423 | -0.01003 |
| SUM1315MO2 | Cisplatin | 0.1 | Chemo | Chemotherapy | 0.7729 | 0.01389 |
| SUM1315MO2 | Cisplatin | 0.31623 | Chemo | Chemotherapy | 0.7794 | 0.02371 |
| SUM1315MO2 | Cisplatin | 1.0 | Chemo | Chemotherapy | 0.5011 | 0.13135 |