Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1428 Palbociclib
0.1
CDK4/6
Cell cycle
 0.4404 0.00070
HCC1428 Palbociclib
0.31623
CDK4/6
Cell cycle
 0.3193 0.01427
HCC1428 Palbociclib
1.0
CDK4/6
Cell cycle
 0.2542 0.00961
HCC1428 Palbociclib
3.1623
CDK4/6
Cell cycle
 0.2853 0.00831
HCC1428 AZD7762
0.001
CHK1/2
Cell cycle
 1.1438 -0.00336
HCC1428 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.2521 -0.00322
HCC1428 AZD7762
0.01
CHK1/2
Cell cycle
 1.1457 0.00219
HCC1428 AZD7762
0.031623
CHK1/2
Cell cycle
 1.1293 0.00825
HCC1428 AZD7762
0.1
CHK1/2
Cell cycle
 0.8585 0.04415
HCC1428 AZD7762
0.31623
CHK1/2
Cell cycle
 0.5216 0.08493
HCC1428 AZD7762
1.0
CHK1/2
Cell cycle
 0.2071 0.13909
HCC1428 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.1631 0.21934
HCC1428 AZD7762
10.0
CHK1/2
Cell cycle
 -0.2152 0.26764
HCC1428 Volasertib
0.0001
PLK
Cell cycle
 1.0147 -0.00483
HCC1428 Volasertib
0.00031623
PLK
Cell cycle
 1.1120 -0.00020
HCC1428 Volasertib
0.001
PLK
Cell cycle
 1.0616 0.00191
HCC1428 Volasertib
0.0031623
PLK
Cell cycle
 1.0689 0.00071
HCC1428 Volasertib
0.01
PLK
Cell cycle
 0.7735 0.05093
HCC1428 Volasertib
0.031623
PLK
Cell cycle
 0.2499 0.18722
HCC1428 Volasertib
0.1
PLK
Cell cycle
 0.0515 0.23176
HCC1428 Volasertib
0.31623
PLK
Cell cycle
 0.0371 0.18557
HCC1428 Volasertib
1.0
PLK
Cell cycle
 -0.0388 0.17194
HCC1428 Dinaciclib
0.0001
pan CDK
Cell cycle
 1.0775 0.00265
HCC1428 Dinaciclib
0.00031623
pan CDK
Cell cycle
 1.0778 0.00086
HCC1428 Dinaciclib
0.001
pan CDK
Cell cycle
 0.9813 -0.00109