Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
T47D Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.4183 0.41244
T47D Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.9813 0.00301
T47D Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9908 0.00341
T47D Pictilisib
0.01
pan PI3K
PI3K/mTOR
 0.9258 -0.00021
T47D Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.7446 0.00475
T47D Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.5721 0.00545
T47D Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.3369 0.01649
T47D Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.1470 0.02290
T47D Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.0478 0.04547
T47D Pictilisib
10.0
pan PI3K
PI3K/mTOR
 -0.1470 0.20081
T47D Ceritinib
0.001
ALK
RTK
 1.0062 0.00143
T47D Ceritinib
0.0031623
ALK
RTK
 1.0140 -0.00096
T47D Ceritinib
0.01
ALK
RTK
 1.0195 0.00391
T47D Ceritinib
0.031623
ALK
RTK
 0.9800 0.00232
T47D Ceritinib
0.1
ALK
RTK
 0.8770 0.00070
T47D Ceritinib
0.31623
ALK
RTK
 0.7724 0.00245
T47D Ceritinib
1.0
ALK
RTK
 0.6886 0.01126
T47D Ceritinib
3.1623
ALK
RTK
 0.0744 0.17622
T47D Ceritinib
10.0
ALK
RTK
 -0.8550 0.88984
T47D Neratinib
0.00031623
EGFR/HER2
RTK
 1.0300 -0.00340
T47D Neratinib
0.001
EGFR/HER2
RTK
 0.9912 0.00546
T47D Neratinib
0.0031623
EGFR/HER2
RTK
 0.9243 0.00235
T47D Neratinib
0.01
EGFR/HER2
RTK
 0.8992 0.00476
T47D Neratinib
0.031623
EGFR/HER2
RTK
 0.7538 0.00426
T47D Neratinib
0.1
EGFR/HER2
RTK
 0.6690 0.00126