Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
T47D INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.9201 -0.00207
T47D INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.6751 0.00849
T47D INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.2753 0.01646
T47D INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.0771 0.02991
T47D INK-128
0.1
mTORC1/2
PI3K/mTOR
 0.0285 0.02953
T47D INK-128
0.31623
mTORC1/2
PI3K/mTOR
 0.0187 0.03759
T47D INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.0081 0.03583
T47D INK-128
3.1623
mTORC1/2
PI3K/mTOR
 -0.0486 0.05668
T47D PF-4708671
0.001
p70S6K
PI3K/mTOR
 1.0815 0.00107
T47D PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 1.0654 0.00207
T47D PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.0634 0.00005
T47D PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0128 0.00308
T47D PF-4708671
0.1
p70S6K
PI3K/mTOR
 0.9897 -0.00304
T47D PF-4708671
0.31623
p70S6K
PI3K/mTOR
 0.8864 0.00511
T47D PF-4708671
1.0
p70S6K
PI3K/mTOR
 0.7379 0.00196
T47D PF-4708671
3.1623
p70S6K
PI3K/mTOR
 0.5451 0.00403
T47D PF-4708671
10.0
p70S6K
PI3K/mTOR
 0.3659 0.00725
T47D Buparlisib
0.001
pan PI3K
PI3K/mTOR
 1.0361 0.00155
T47D Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9732 0.00324
T47D Buparlisib
0.01
pan PI3K
PI3K/mTOR
 0.9889 0.00001
T47D Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 0.8923 0.00823
T47D Buparlisib
0.1
pan PI3K
PI3K/mTOR
 0.6327 0.00575
T47D Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.4339 0.01153
T47D Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.1266 0.03434
T47D Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.2136 0.30278