Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
T47D AZD7762
10.0
CHK1/2
Cell cycle
 -0.0573 0.09637
T47D Volasertib
0.0001
PLK
Cell cycle
 1.0700 0.00171
T47D Volasertib
0.00031623
PLK
Cell cycle
 1.1177 -0.00040
T47D Volasertib
0.001
PLK
Cell cycle
 1.0155 -0.00006
T47D Volasertib
0.0031623
PLK
Cell cycle
 1.0642 -0.00098
T47D Volasertib
0.01
PLK
Cell cycle
 0.8485 0.00521
T47D Volasertib
0.031623
PLK
Cell cycle
 0.5177 0.04885
T47D Volasertib
0.1
PLK
Cell cycle
 -0.0044 0.13769
T47D Volasertib
0.31623
PLK
Cell cycle
 -0.0906 0.16641
T47D Volasertib
1.0
PLK
Cell cycle
 -0.1585 0.16311
T47D Dinaciclib
0.0001
pan CDK
Cell cycle
 0.9929 0.00094
T47D Dinaciclib
0.00031623
pan CDK
Cell cycle
 0.9825 0.00122
T47D Dinaciclib
0.001
pan CDK
Cell cycle
 1.0782 -0.00177
T47D Dinaciclib
0.0031623
pan CDK
Cell cycle
 1.1013 -0.00122
T47D Dinaciclib
0.01
pan CDK
Cell cycle
 1.0605 0.00600
T47D Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.0592 0.05833
T47D Dinaciclib
0.1
pan CDK
Cell cycle
 -0.1265 0.09974
T47D Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.1896 0.14363
T47D Dinaciclib
1.0
pan CDK
Cell cycle
 -0.2109 0.12913
T47D Cisplatin
0.0010833
Chemo
Chemotherapy
 1.0538 -0.00313
T47D Cisplatin
0.0033333
Chemo
Chemotherapy
 1.0424 0.00001
T47D Cisplatin
0.01
Chemo
Chemotherapy
 0.9732 -0.00029
T47D Cisplatin
0.031667
Chemo
Chemotherapy
 1.0050 -0.00066
T47D Cisplatin
0.1
Chemo
Chemotherapy
 0.9180 -0.00007
T47D Cisplatin
0.31623
Chemo
Chemotherapy
 0.8420 -0.00135