Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
PDXHCI002 Saracatinib
0.31623
SRC
MAPK/nRTK
 0.3167 0.02388
PDXHCI002 Saracatinib
1.0
SRC
MAPK/nRTK
 0.1856 0.01792
PDXHCI002 Saracatinib
3.1623
SRC
MAPK/nRTK
 0.1026 0.03726
PDXHCI002 Saracatinib
10.0
SRC
MAPK/nRTK
 0.0015 0.04231
PDXHCI002 ABT-737
0.001
Bcl2/XL
Misc
 1.0866 0.00324
PDXHCI002 ABT-737
0.0031623
Bcl2/XL
Misc
 1.0393 -0.00057
PDXHCI002 ABT-737
0.01
Bcl2/XL
Misc
 1.0896 -0.00162
PDXHCI002 ABT-737
0.031623
Bcl2/XL
Misc
 1.1096 0.00923
PDXHCI002 ABT-737
0.1
Bcl2/XL
Misc
 1.0469 0.01207
PDXHCI002 ABT-737
0.31623
Bcl2/XL
Misc
 1.0148 0.01436
PDXHCI002 ABT-737
1.0
Bcl2/XL
Misc
 0.8897 0.03485
PDXHCI002 ABT-737
3.1623
Bcl2/XL
Misc
 0.7559 0.04710
PDXHCI002 ABT-737
10.0
Bcl2/XL
Misc
 0.1456 0.15660
PDXHCI002 Vorinostat
0.001
HDAC
Misc
 1.0404 -0.00323
PDXHCI002 Vorinostat
0.0031623
HDAC
Misc
 1.0220 0.00256
PDXHCI002 Vorinostat
0.01
HDAC
Misc
 1.0002 -0.00230
PDXHCI002 Vorinostat
0.031623
HDAC
Misc
 0.9803 0.01320
PDXHCI002 Vorinostat
0.1
HDAC
Misc
 0.7264 0.07144
PDXHCI002 Vorinostat
0.31623
HDAC
Misc
 0.5298 0.13858
PDXHCI002 Vorinostat
1.0
HDAC
Misc
 -0.2956 0.60310
PDXHCI002 Vorinostat
3.1623
HDAC
Misc
 -0.5508 0.74305
PDXHCI002 Vorinostat
10.0
HDAC
Misc
 -0.5830 0.74871
PDXHCI002 Luminespib
0.0001
HSP90
Misc
 1.0670 0.00520
PDXHCI002 Luminespib
0.00031623
HSP90
Misc
 1.0840 -0.00274
PDXHCI002 Luminespib
0.001
HSP90
Misc
 1.0899 0.00034