Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
PDX1328 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.3715 0.24133
BT-20 Tivantinib
10.0
MET
RTK
 -0.3705 0.51103
HCC1954 Luminespib
0.31623
HSP90
Misc
 -0.3702 0.66159
SUM149PT Luminespib
0.031623
HSP90
Misc
 -0.3697 0.68596
CAL-85-1 Doxorubicin
3.1623
Chemo
Chemotherapy
 -0.3695 0.35199
HCC1500 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 -0.3695 0.32842
HCC1143 AZD7762
10.0
CHK1/2
Cell cycle
 -0.3693 0.49106
HCC1954 Topotecan
3.1623
Topo I
Chemotherapy
 -0.3693 0.64841
SUM1315MO2 Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.3686 0.37110
SK-BR-3 INK-128
1.0
mTORC1/2
PI3K/mTOR
 -0.3684 0.45002
HCC38 Doxorubicin
3.1623
Chemo
Chemotherapy
 -0.3683 0.59119
Hs 578T Taxol
0.1
Chemo
Chemotherapy
 -0.3681 0.72674
HCC1937 Topotecan
1.0
Topo I
Chemotherapy
 -0.3676 0.61187
MDA-MB-231 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.3669 0.58629
MDA-MB-468 Doxorubicin
0.1
Chemo
Chemotherapy
 -0.3660 0.51446
SK-BR-3 Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.3659 0.43154
MDA-MB-134-VI AZD7762
1.0
CHK1/2
Cell cycle
 -0.3651 0.21541
HCC1806 Cisplatin
10.0
Chemo
Chemotherapy
 -0.3648 0.50046
MDA-MB-157 Taxol
0.031623
Chemo
Chemotherapy
 -0.3648 0.48642
SUM1315MO2 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.3637 0.33806
HCC1954 Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 -0.3632 0.59079
MDA-MB-231 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.3630 0.59853
HCC1937 AZD7762
10.0
CHK1/2
Cell cycle
 -0.3625 0.52867
MDA-MB-231 Cediranib
10.0
VEGFR/cKIT
RTK
 -0.3620 0.52491
T47D Doxorubicin
1.0
Chemo
Chemotherapy
 -0.3611 0.36359