Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| MDA-MB-361 | Taselisib | 10.0 | PI3Ka, g, d | PI3K/mTOR | -0.9902 | 0.90326 |
| MDA-MB-361 | Ceritinib | 10.0 | ALK | RTK | -0.9910 | 0.89628 |
| T47D | Ceritinib | 10.0 | ALK | RTK | -0.8550 | 0.88984 |
| SUM159PT | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.4677 | 0.88367 |
| MDA-MB-361 | Cediranib | 10.0 | VEGFR/cKIT | RTK | -0.9803 | 0.88037 |
| Hs 578T | AZD7762 | 10.0 | CHK1/2 | Cell cycle | -0.5983 | 0.86377 |
| MDA-MB-361 | Torin2 | 1.0 | mTOR/ATM/ATR | PI3K/mTOR | -0.9642 | 0.85473 |
| MDA-MB-361 | Buparlisib | 10.0 | pan PI3K | PI3K/mTOR | -0.9584 | 0.84606 |
| Hs 578T | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.5825 | 0.84364 |
| BT-20 | Ceritinib | 10.0 | ALK | RTK | -0.7365 | 0.84133 |
| MDA-MB-157 | Ceritinib | 10.0 | ALK | RTK | -0.9264 | 0.83901 |
| MDA-MB-468 | Ceritinib | 10.0 | ALK | RTK | -0.7415 | 0.83751 |
| HCC1428 | Ceritinib | 10.0 | ALK | RTK | -0.8673 | 0.83636 |
| MDA-MB-157 | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.9106 | 0.83515 |
| MDA-MB-157 | Dinaciclib | 0.31623 | pan CDK | Cell cycle | -0.9006 | 0.83378 |
| SUM149PT | Dinaciclib | 0.1 | pan CDK | Cell cycle | -0.5705 | 0.83197 |
| MDA-MB-134-VI | Cediranib | 10.0 | VEGFR/cKIT | RTK | -0.9999 | 0.83082 |
| HCC1428 | Doxorubicin | 3.1623 | Chemo | Chemotherapy | -0.7396 | 0.82745 |
| MDA-MB-361 | Taselisib | 3.1623 | PI3Ka, g, d | PI3K/mTOR | -0.9425 | 0.82696 |
| SUM149PT | Dinaciclib | 0.31623 | pan CDK | Cell cycle | -0.5676 | 0.82399 |
| BT-20 | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.6979 | 0.82310 |
| MDA-MB-361 | Vorinostat | 10.0 | HDAC | Misc | -0.9392 | 0.81668 |
| SUM149PT | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.5605 | 0.81650 |
| Hs 578T | Cediranib | 10.0 | VEGFR/cKIT | RTK | -0.5723 | 0.81093 |
| MDA-MB-134-VI | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.9986 | 0.81070 |