Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| PDXHCI002 | Etoposide | 0.31623 | Topo II | Chemotherapy | 0.3668 | -0.10135 |
| PDXHCI002 | Cisplatin | 3.1623 | Chemo | Chemotherapy | 0.2841 | -0.09181 |
| HCC1500 | Topotecan | 0.0033333 | Topo I | Chemotherapy | 0.5954 | -0.09112 |
| PDXHCI002 | Bleomycin | 1.0 | Radiation | Misc | 0.5681 | -0.08965 |
| PDXHCI002 | Etoposide | 0.1 | Topo II | Chemotherapy | 0.6449 | -0.08531 |
| HCC1500 | Etoposide | 1.0 | Topo II | Chemotherapy | 0.5931 | -0.08322 |
| PDXHCI002 | Bleomycin | 0.31623 | Radiation | Misc | 0.7964 | -0.08259 |
| PDXHCI002 | Topotecan | 0.0033333 | Topo I | Chemotherapy | 0.7862 | -0.07478 |
| HCC1500 | Etoposide | 0.31623 | Topo II | Chemotherapy | 0.9236 | -0.07287 |
| PDXHCI002 | Cisplatin | 1.0 | Chemo | Chemotherapy | 0.6445 | -0.07108 |
| HCC1500 | Cisplatin | 3.1623 | Chemo | Chemotherapy | 0.5843 | -0.07018 |
| PDXHCI002 | Bleomycin | 3.1623 | Radiation | Misc | 0.1591 | -0.06333 |
| PDXHCI002 | INK-128 | 0.031623 | mTORC1/2 | PI3K/mTOR | 0.8875 | -0.05553 |
| PDXHCI002 | Cisplatin | 0.31623 | Chemo | Chemotherapy | 0.9496 | -0.05460 |
| PDXHCI002 | INK-128 | 0.31623 | mTORC1/2 | PI3K/mTOR | 0.4597 | -0.05379 |
| PDXHCI002 | INK-128 | 0.1 | mTORC1/2 | PI3K/mTOR | 0.6193 | -0.05362 |
| PDXHCI002 | INK-128 | 0.01 | mTORC1/2 | PI3K/mTOR | 1.3353 | -0.05354 |
| PDXHCI002 | Etoposide | 0.031667 | Topo II | Chemotherapy | 0.9100 | -0.05329 |
| PDXHCI002 | Torin2 | 0.031623 | mTOR/ATM/ATR | PI3K/mTOR | 0.9514 | -0.05278 |
| PDXHCI002 | Everolimus | 0.31623 | mTOR1 | PI3K/mTOR | 1.1168 | -0.05253 |
| PDXHCI002 | Etoposide | 3.1623 | Topo II | Chemotherapy | -0.0891 | -0.05192 |
| PDXHCI002 | Everolimus | 0.1 | mTOR1 | PI3K/mTOR | 1.1029 | -0.05190 |
| PDXHCI002 | Topotecan | 0.01 | Topo I | Chemotherapy | 0.3231 | -0.04961 |
| PDXHCI002 | Everolimus | 0.031623 | mTOR1 | PI3K/mTOR | 1.1053 | -0.04958 |
| PDXHCI002 | Torin2 | 0.01 | mTOR/ATM/ATR | PI3K/mTOR | 1.4354 | -0.04922 |