Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| SUM159PT | Buparlisib | 0.031623 | pan PI3K | PI3K/mTOR | 0.9963 | -0.00253 |
| SUM159PT | Buparlisib | 0.1 | pan PI3K | PI3K/mTOR | 1.0017 | -0.00187 |
| SUM159PT | Buparlisib | 0.31623 | pan PI3K | PI3K/mTOR | 0.9105 | -0.00430 |
| SUM159PT | Buparlisib | 1.0 | pan PI3K | PI3K/mTOR | 0.7058 | -0.00009 |
| SUM159PT | Buparlisib | 3.1623 | pan PI3K | PI3K/mTOR | 0.1570 | 0.09455 |
| SUM159PT | Buparlisib | 10.0 | pan PI3K | PI3K/mTOR | -0.1942 | 0.45888 |
| SUM159PT | Pictilisib | 0.001 | pan PI3K | PI3K/mTOR | 0.9957 | 0.00061 |
| SUM159PT | Pictilisib | 0.0031623 | pan PI3K | PI3K/mTOR | 0.9930 | -0.00213 |
| SUM159PT | Pictilisib | 0.01 | pan PI3K | PI3K/mTOR | 0.9847 | -0.00285 |
| SUM159PT | Pictilisib | 0.031623 | pan PI3K | PI3K/mTOR | 0.9822 | -0.00455 |
| SUM159PT | Pictilisib | 0.1 | pan PI3K | PI3K/mTOR | 0.9298 | -0.00468 |
| SUM159PT | Pictilisib | 0.31623 | pan PI3K | PI3K/mTOR | 0.8144 | -0.00692 |
| SUM159PT | Pictilisib | 1.0 | pan PI3K | PI3K/mTOR | 0.5262 | -0.00713 |
| SUM159PT | Pictilisib | 3.1623 | pan PI3K | PI3K/mTOR | 0.3124 | -0.00003 |
| SUM159PT | Pictilisib | 10.0 | pan PI3K | PI3K/mTOR | 0.0942 | 0.00650 |
| SUM159PT | Ceritinib | 0.001 | ALK | RTK | 0.9891 | 0.00112 |
| SUM159PT | Ceritinib | 0.0031623 | ALK | RTK | 0.9902 | 0.00337 |
| SUM159PT | Ceritinib | 0.01 | ALK | RTK | 1.0080 | -0.00023 |
| SUM159PT | Ceritinib | 0.031623 | ALK | RTK | 0.9871 | -0.00104 |
| SUM159PT | Ceritinib | 0.1 | ALK | RTK | 0.9864 | -0.00012 |
| SUM159PT | Ceritinib | 0.31623 | ALK | RTK | 0.9368 | 0.00183 |
| SUM159PT | Ceritinib | 1.0 | ALK | RTK | 0.7932 | 0.00327 |
| SUM159PT | Ceritinib | 3.1623 | ALK | RTK | -0.0787 | 0.47423 |
| SUM159PT | Ceritinib | 10.0 | ALK | RTK | -0.3800 | 0.80163 |
| SUM159PT | Neratinib | 0.00031623 | EGFR/HER2 | RTK | 1.0083 | -0.00349 |