Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM149PT Alpelisib
0.01
PI3Ka
PI3K/mTOR
 1.0172 0.00171
SUM149PT Alpelisib
0.031623
PI3Ka
PI3K/mTOR
 1.0085 -0.00097
SUM149PT Alpelisib
0.1
PI3Ka
PI3K/mTOR
 0.9771 0.00353
SUM149PT Alpelisib
0.31623
PI3Ka
PI3K/mTOR
 0.9787 -0.00013
SUM149PT Alpelisib
1.0
PI3Ka
PI3K/mTOR
 0.8985 0.02432
SUM149PT Alpelisib
3.1623
PI3Ka
PI3K/mTOR
 0.9259 0.00471
SUM149PT Alpelisib
10.0
PI3Ka
PI3K/mTOR
 0.8446 0.02425
SUM149PT Taselisib
0.001
PI3Ka, g, d
PI3K/mTOR
 0.9689 0.00587
SUM149PT Taselisib
0.0031623
PI3Ka, g, d
PI3K/mTOR
 0.9970 -0.00035
SUM149PT Taselisib
0.01
PI3Ka, g, d
PI3K/mTOR
 0.9841 0.00313
SUM149PT Taselisib
0.031623
PI3Ka, g, d
PI3K/mTOR
 0.9607 0.00711
SUM149PT Taselisib
0.1
PI3Ka, g, d
PI3K/mTOR
 0.9404 0.00345
SUM149PT Taselisib
0.31623
PI3Ka, g, d
PI3K/mTOR
 0.8611 0.01377
SUM149PT Taselisib
1.0
PI3Ka, g, d
PI3K/mTOR
 0.7151 0.01790
SUM149PT Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 0.4950 0.04040
SUM149PT Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 -0.2343 0.60552
SUM149PT TGX221
0.001
PI3Kb
PI3K/mTOR
 1.0242 0.00220
SUM149PT TGX221
0.0031623
PI3Kb
PI3K/mTOR
 1.0391 0.00161
SUM149PT TGX221
0.01
PI3Kb
PI3K/mTOR
 1.0299 -0.00048
SUM149PT TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.0301 -0.00025
SUM149PT TGX221
0.1
PI3Kb
PI3K/mTOR
 1.0209 0.00281
SUM149PT TGX221
0.31623
PI3Kb
PI3K/mTOR
 1.0076 -0.00261
SUM149PT TGX221
1.0
PI3Kb
PI3K/mTOR
 1.0073 0.00107
SUM149PT TGX221
3.1623
PI3Kb
PI3K/mTOR
 1.0187 0.00033
SUM149PT TGX221
10.0
PI3Kb
PI3K/mTOR
 1.0138 0.00067