LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Dasatinib | 85.43 | 12.0 | Inf | Inf | -0.8540 | -0.8540 | 0.0000 | 0.9401 |
| MCF 10A-H2B-mCherry | Vorinostat | 85.43 | 12.0 | Inf | Inf | 0.1293 | 0.1293 | 0.0000 | 0.6446 |
| MCF 10A-H2B-mCherry | Trametinib | 85.43 | 12.0 | Inf | Inf | 0.0802 | 0.0802 | 0.0000 | 0.6023 |
| MCF 10A-H2B-mCherry | Neratinib | 85.43 | 12.0 | Inf | Inf | -0.8789 | -0.8789 | 0.0000 | 0.5982 |
| MCF 10A-H2B-mCherry | Alpelisib | 85.43 | 12.0 | Inf | Inf | -0.9870 | -0.9870 | 0.0000 | 0.8881 |
| MCF 10A-H2B-mCherry | Palbociclib | 85.43 | 12.0 | Inf | Inf | -0.9908 | -0.9912 | 0.5687 | 0.5120 |
| MCF 10A-H2B-mCherry | Etoposide | 85.43 | 12.0 | Inf | Inf | -0.8811 | -0.8811 | 0.0000 | 1.1884 |
| MCF 10A-H2B-mCherry | Taxol | 85.43 | 12.0 | Inf | Inf | -0.9704 | -0.7957 | 2.4990 | 1.5206 |
| MCF 10A-H2B-mCherry | Alpelisib | 25.30 | 11.9 | Inf | 2.7919 | 0.5162 | 0.5717 | 4.5032 | 0.1028 |
| MCF 10A-H2B-mCherry | Alpelisib | 33.82 | 11.9 | 17.7359 | 26.237 | 0.6412 | -0.5037 | 1.1924 | 0.0475 |
| MCF 10A-H2B-mCherry | Alpelisib | 23.60 | 11.9 | Inf | Inf | 0.5168 | 0.4975 | 2.5000 | 0.1285 |
| MCF 10A-H2B-mCherry | Alpelisib | 35.52 | 11.9 | 17.5986 | 36.6414 | 0.6041 | -0.0856 | 2.8588 | 0.0554 |
| MCF 10A-H2B-mCherry | Alpelisib | 37.23 | 11.9 | Inf | 26.561 | 0.6750 | -0.1747 | 3.0317 | 0.0360 |
| MCF 10A-H2B-mCherry | Alpelisib | 38.93 | 11.9 | Inf | 6.4483 | 0.6837 | 0.6427 | 5.0000 | 0.0115 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.49 | 11.9 | Inf | Inf | 0.4464 | 0.5217 | 2.5000 | 0.1547 |
| MCF 10A-H2B-mCherry | Alpelisib | 32.11 | 11.9 | Inf | 17.6088 | 0.6518 | -0.2106 | 0.9909 | 0.0628 |
| MCF 10A-H2B-mCherry | Alpelisib | 47.45 | 11.9 | Inf | Inf | 0.7990 | 0.8167 | 0.9724 | 0.0230 |
| MCF 10A-H2B-mCherry | Alpelisib | 30.41 | 11.9 | Inf | 15.4577 | 0.6412 | -0.1329 | 1.0881 | 0.0751 |
| MCF 10A-H2B-mCherry | Alpelisib | 21.90 | 11.9 | Inf | Inf | 0.4426 | 0.4238 | 2.5000 | 0.1686 |
| MCF 10A-H2B-mCherry | Alpelisib | 49.15 | 11.9 | Inf | Inf | 0.8148 | 0.8290 | 2.4998 | 0.0068 |
| MCF 10A-H2B-mCherry | Alpelisib | 50.86 | 11.9 | Inf | Inf | 0.8643 | 0.8641 | 2.5000 | 0.0066 |
| MCF 10A-H2B-mCherry | Alpelisib | 52.56 | 11.9 | Inf | Inf | 0.8858 | 0.8764 | 2.5000 | -0.0107 |
| MCF 10A-H2B-mCherry | Alpelisib | 54.25 | 11.9 | Inf | Inf | 0.9331 | 0.9259 | 2.5000 | -0.0161 |
| MCF 10A-H2B-mCherry | Alpelisib | 45.74 | 11.9 | Inf | Inf | 0.8089 | 0.1521 | 0.3040 | 0.0556 |
| MCF 10A-H2B-mCherry | Alpelisib | 44.03 | 11.9 | Inf | Inf | 0.8013 | -0.0883 | 0.3719 | 0.0392 |