LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Taxol | 89.69 | 11.9 | 0.0001 | 0.0001 | -0.3321 | -0.7000 | 4.9958 | 1.5687 |
| MCF 10A-H2B-mCherry | Taxol | 80.31 | 11.9 | 0.0 | 0.0002 | -1.0000 | -0.8852 | 0.6794 | 1.4491 |
| MCF 10A-H2B-mCherry | Taxol | 76.90 | 11.9 | 0.0001 | 0.0003 | -0.9743 | -0.6652 | 0.7092 | 1.2470 |
| MCF 10A-H2B-mCherry | Trametinib | 20.19 | 11.9 | 0.0012 | 0.0012 | 0.2434 | 0.3423 | 3.2856 | 0.5482 |
| MCF 10A-H2B-mCherry | Taxol | 44.03 | 11.9 | 0.0009 | 0.0013 | -0.6620 | -0.5136 | 2.4572 | 0.9282 |
| MCF 10A-H2B-mCherry | Taxol | 45.74 | 11.9 | 0.001 | 0.0013 | -0.5327 | -0.4972 | 2.3910 | 0.9179 |
| MCF 10A-H2B-mCherry | Taxol | 40.63 | 11.9 | 0.0009 | 0.0013 | -0.6378 | -0.4639 | 2.4621 | 0.8999 |
| MCF 10A-H2B-mCherry | Taxol | 42.33 | 11.9 | 0.0009 | 0.0013 | -0.6426 | -0.5128 | 2.3074 | 0.9302 |
| MCF 10A-H2B-mCherry | Taxol | 38.93 | 11.9 | 0.001 | 0.0013 | -0.6088 | -0.4753 | 2.3261 | 0.8982 |
| MCF 10A-H2B-mCherry | Taxol | 50.86 | 11.9 | 0.0011 | 0.0014 | -0.6471 | -0.4615 | 2.5981 | 0.9039 |
| MCF 10A-H2B-mCherry | Trametinib | 28.71 | 11.9 | 0.0019 | 0.0014 | 0.0832 | 0.1492 | 1.8509 | 0.6520 |
| MCF 10A-H2B-mCherry | Taxol | 49.15 | 11.9 | 0.0011 | 0.0014 | -0.7087 | -0.4671 | 2.6462 | 0.8938 |
| MCF 10A-H2B-mCherry | Taxol | 71.30 | 11.9 | 0.001 | 0.0014 | 0.1323 | -0.2625 | 3.2812 | 0.7769 |
| MCF 10A-H2B-mCherry | Trametinib | 25.30 | 11.9 | 0.0017 | 0.0014 | 0.1022 | 0.1419 | 1.1785 | 0.6613 |
| MCF 10A-H2B-mCherry | Taxol | 54.25 | 11.9 | 0.0012 | 0.0014 | -0.5929 | -0.3570 | 3.0694 | 0.8324 |
| MCF 10A-H2B-mCherry | Taxol | 47.45 | 11.9 | 0.001 | 0.0014 | -0.6791 | -0.5351 | 2.4484 | 0.9236 |
| MCF 10A-H2B-mCherry | Taxol | 37.23 | 11.9 | 0.001 | 0.0014 | -0.5921 | -0.4954 | 2.0788 | 0.8997 |
| MCF 10A-H2B-mCherry | Trametinib | 21.90 | 11.9 | 0.0013 | 0.0014 | 0.1822 | 0.2336 | 1.5224 | 0.6197 |
| MCF 10A-H2B-mCherry | Trametinib | 23.60 | 11.9 | 0.0013 | 0.0015 | 0.2225 | 0.1793 | 1.2585 | 0.6490 |
| MCF 10A-H2B-mCherry | Taxol | 35.52 | 11.9 | 0.0011 | 0.0016 | -0.6623 | -0.5487 | 1.8986 | 0.9134 |
| MCF 10A-H2B-mCherry | Trametinib | 27.00 | 11.9 | 0.0019 | 0.0016 | 0.0473 | 0.1162 | 1.2836 | 0.6659 |
| MCF 10A-H2B-mCherry | Taxol | 52.56 | 11.9 | 0.0012 | 0.0016 | -0.7607 | -0.5550 | 2.7936 | 0.9382 |
| MCF 10A-H2B-mCherry | Taxol | 67.89 | 11.9 | 0.0011 | 0.0016 | -0.4845 | -0.5264 | 3.3721 | 0.9248 |
| MCF 10A-H2B-mCherry | Taxol | 59.37 | 11.9 | 0.0014 | 0.0017 | -0.5953 | -0.4995 | 4.0561 | 0.9069 |
| MCF 10A-H2B-mCherry | Taxol | 62.78 | 11.9 | 0.0014 | 0.0017 | -0.6938 | -0.5140 | 4.2755 | 0.9151 |