LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Neratinib | 15.08 | 11.9 | 0.0426 | 0.0275 | 0.1256 | 0.3067 | 3.0534 | 0.4072 |
| MCF 10A-H2B-mCherry | Dasatinib | 15.08 | 11.9 | Inf | Inf | 0.1243 | -0.4244 | 0.2057 | 0.3924 |
| MCF 10A-H2B-mCherry | Alpelisib | 15.08 | 11.9 | Inf | Inf | 0.4895 | 0.4895 | 0.0000 | 0.1563 |
| MCF 10A-H2B-mCherry | Etoposide | 15.08 | 11.9 | Inf | Inf | 0.0410 | -0.3362 | 0.4618 | 0.2363 |
| MCF 10A-H2B-mCherry | Vorinostat | 15.08 | 11.9 | 0.692 | 0.9855 | -0.3793 | -0.3371 | 1.5502 | 0.4019 |
| MCF 10A-H2B-mCherry | Trametinib | 15.08 | 11.9 | Inf | Inf | 0.3411 | 0.3411 | 0.0000 | 0.3691 |
| MCF 10A-H2B-mCherry | Palbociclib | 15.08 | 11.9 | Inf | Inf | 0.1532 | 0.1532 | 0.0000 | 0.4065 |
| MCF 10A-H2B-mCherry | Taxol | 15.08 | 11.9 | 0.0045 | 0.019 | -0.5767 | -0.8583 | 0.7179 | 0.6695 |
| MCF 10A-H2B-mCherry | Taxol | 16.79 | 11.9 | 0.0027 | 0.0126 | -0.6222 | -0.8419 | 0.7095 | 0.7366 |
| MCF 10A-H2B-mCherry | Vorinostat | 16.79 | 11.9 | 0.597 | 0.8322 | -0.3837 | -0.3140 | 1.5509 | 0.4157 |
| MCF 10A-H2B-mCherry | Palbociclib | 16.79 | 11.9 | Inf | Inf | 0.1194 | -0.3957 | 0.0878 | 0.4436 |
| MCF 10A-H2B-mCherry | Trametinib | 16.79 | 11.9 | Inf | Inf | 0.4137 | 0.4380 | 0.6914 | 0.4102 |
| MCF 10A-H2B-mCherry | Dasatinib | 16.79 | 11.9 | Inf | Inf | 0.0863 | -0.4330 | 0.2049 | 0.4204 |
| MCF 10A-H2B-mCherry | Neratinib | 16.79 | 11.9 | 0.0408 | 0.0286 | 0.0286 | 0.2638 | 3.0072 | 0.4249 |
| MCF 10A-H2B-mCherry | Etoposide | 16.79 | 11.9 | 2.2187 | 15.6011 | 0.0196 | -1.0000 | 0.6178 | 0.2349 |
| MCF 10A-H2B-mCherry | Alpelisib | 16.79 | 11.9 | Inf | Inf | 0.4687 | 0.5844 | 2.5000 | 0.1607 |
| MCF 10A-H2B-mCherry | Vorinostat | 18.49 | 11.9 | 0.5769 | 0.7432 | -0.3615 | -0.2481 | 1.6710 | 0.4087 |
| MCF 10A-H2B-mCherry | Taxol | 18.49 | 11.9 | 0.0018 | 0.0057 | -0.6429 | -0.7171 | 0.7731 | 0.7994 |
| MCF 10A-H2B-mCherry | Etoposide | 18.49 | 11.9 | 1.6291 | 11.8949 | 0.0238 | -1.0000 | 0.5835 | 0.2602 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.49 | 11.9 | Inf | Inf | 0.4464 | 0.5217 | 2.5000 | 0.1547 |
| MCF 10A-H2B-mCherry | Palbociclib | 18.49 | 11.9 | Inf | Inf | 0.0520 | -0.4305 | 0.1045 | 0.4625 |
| MCF 10A-H2B-mCherry | Dasatinib | 18.49 | 11.9 | Inf | Inf | 0.0602 | -0.3489 | 0.2088 | 0.4503 |
| MCF 10A-H2B-mCherry | Neratinib | 18.49 | 11.9 | 0.0349 | 0.027 | -0.0435 | 0.1298 | 0.9796 | 0.4721 |
| MCF 10A-H2B-mCherry | Trametinib | 18.49 | 11.9 | Inf | Inf | 0.3116 | 0.3689 | 2.5000 | 0.4518 |
| MCF 10A-H2B-mCherry | Taxol | 20.19 | 11.9 | 0.0017 | 0.004 | -0.7188 | -0.6844 | 1.0554 | 0.8484 |