LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 9 of 15: End-point dose-response metrics for biological replicate 3. - Dataset (ID:20317)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 84 | 0.8613 | 1.1591 | -0.0588 | -0.1971 | 1.1191 | 0.3611 |
| MCF 10A-H2B-mCherry | Etoposide | 84 | 0.3533 | 0.6359 | 0.1344 | -0.1515 | 0.4501 | 0.4060 |
| MCF 10A-H2B-mCherry | Neratinib | 84 | 0.2629 | 2.4045 | -0.1966 | -1.0000 | 0.4964 | 0.3709 |
| MCF 10A-H2B-mCherry | Dasatinib | 84 | 0.5642 | 58.6317 | -0.0543 | -1.0000 | 0.2366 | 0.3960 |
| MCF 10A-H2B-mCherry | Taxol | 84 | 0.0009 | 0.0012 | -0.3444 | -0.2890 | 1.3812 | 0.8153 |
| MCF 10A-H2B-mCherry | Alpelisib | 84 | Inf | Inf | 0.7193 | 0.7193 | 0.0000 | 0.1230 |
| MCF 10A-H2B-mCherry | Trametinib | 84 | 0.1232 | 0.0231 | 0.3664 | 0.2222 | 0.3508 | 0.3587 |
| MCF 10A-H2B-mCherry | Palbociclib | 84 | 2.3696 | 134.4749 | 0.1665 | -1.0000 | 0.2720 | 0.2965 |
| MCF 10A-H2B-mCherry | Taxol | 72 | 0.001 | 0.0013 | -0.3180 | -0.2585 | 1.4036 | 0.7880 |
| MCF 10A-H2B-mCherry | Vorinostat | 72 | 0.8282 | 1.127 | -0.0873 | -0.2023 | 1.1031 | 0.3632 |
| MCF 10A-H2B-mCherry | Alpelisib | 72 | Inf | Inf | 0.7448 | 0.7448 | 0.0000 | 0.1385 |
| MCF 10A-H2B-mCherry | Trametinib | 72 | 0.0717 | 0.0063 | 0.3482 | 0.3285 | 0.4390 | 0.3784 |
| MCF 10A-H2B-mCherry | Etoposide | 72 | 0.5612 | 1.2244 | 0.1419 | -0.2015 | 0.4341 | 0.3610 |
| MCF 10A-H2B-mCherry | Dasatinib | 72 | 0.8672 | 64.7283 | 0.0603 | -1.0000 | 0.2547 | 0.3653 |
| MCF 10A-H2B-mCherry | Neratinib | 72 | 0.246 | 2.6692 | -0.1124 | -1.0000 | 0.4607 | 0.3588 |
| MCF 10A-H2B-mCherry | Palbociclib | 72 | 2.3133 | 319.7903 | 0.2433 | -1.0000 | 0.2229 | 0.3116 |
| MCF 10A-H2B-mCherry | Dasatinib | 60 | 1.0757 | 102.3859 | 0.1735 | -1.0000 | 0.2412 | 0.3555 |
| MCF 10A-H2B-mCherry | Vorinostat | 60 | 0.7223 | 1.0618 | -0.0810 | -0.2268 | 0.9711 | 0.3866 |
| MCF 10A-H2B-mCherry | Alpelisib | 60 | Inf | Inf | 0.7342 | 0.7342 | 0.0000 | 0.1444 |
| MCF 10A-H2B-mCherry | Etoposide | 60 | 0.847 | 16.3367 | 0.1412 | -0.8621 | 0.3387 | 0.3416 |
| MCF 10A-H2B-mCherry | Neratinib | 60 | 0.2207 | 3.2708 | -0.0756 | -1.0000 | 0.4075 | 0.3689 |
| MCF 10A-H2B-mCherry | Taxol | 60 | 0.0011 | 0.0014 | -0.3195 | -0.2487 | 1.3756 | 0.7703 |
| MCF 10A-H2B-mCherry | Palbociclib | 60 | 2.6707 | 808.9177 | 0.3136 | -1.0000 | 0.1923 | 0.3179 |
| MCF 10A-H2B-mCherry | Trametinib | 60 | 0.2951 | 0.0015 | 0.5078 | 0.4730 | 0.5502 | 0.3764 |
| MCF 10A-H2B-mCherry | Trametinib | 48 | Inf | 0.0005 | 0.5447 | 0.5288 | 0.5177 | 0.3751 |