LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 9 of 15: End-point dose-response metrics for biological replicate 3. - Dataset (ID:20317)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Palbociclib | 12 | Inf | Inf | 0.5376 | 0.5376 | 0.0000 | 0.4133 |
| MCF 10A-H2B-mCherry | Dasatinib | 12 | Inf | Inf | 0.3669 | 0.3669 | 0.0000 | 0.4736 |
| MCF 10A-H2B-mCherry | Vorinostat | 12 | Inf | Inf | 0.2827 | 0.2827 | 0.0000 | 0.5365 |
| MCF 10A-H2B-mCherry | Taxol | 12 | 0.0017 | 2.6985 | 0.1492 | -1.0000 | 0.1490 | 0.5622 |
| MCF 10A-H2B-mCherry | Alpelisib | 12 | Inf | Inf | 0.6300 | 0.6300 | 0.0000 | 0.3905 |
| MCF 10A-H2B-mCherry | Etoposide | 12 | Inf | Inf | 0.3340 | 0.3340 | 0.0000 | 0.4725 |
| MCF 10A-H2B-mCherry | Neratinib | 12 | Inf | Inf | 0.2348 | 0.2348 | 0.0000 | 0.4770 |
| MCF 10A-H2B-mCherry | Trametinib | 12 | Inf | Inf | 0.5665 | 0.5665 | 0.0000 | 0.4216 |
| MCF 10A-H2B-mCherry | Taxol | 24 | 0.002 | 0.0084 | -0.2083 | -0.5081 | 0.4902 | 0.6573 |
| MCF 10A-H2B-mCherry | Trametinib | 24 | Inf | Inf | 0.6669 | 0.6669 | 0.0000 | 0.3246 |
| MCF 10A-H2B-mCherry | Alpelisib | 24 | Inf | Inf | 0.6568 | 0.6568 | 0.0000 | 0.2481 |
| MCF 10A-H2B-mCherry | Vorinostat | 24 | 0.4754 | 1.7724 | -0.0276 | -0.4821 | 0.5130 | 0.4423 |
| MCF 10A-H2B-mCherry | Palbociclib | 24 | Inf | Inf | 0.4526 | 0.4526 | 0.0000 | 0.3423 |
| MCF 10A-H2B-mCherry | Neratinib | 24 | 0.0809 | 0.0088 | 0.2144 | 0.3494 | 0.5423 | 0.4143 |
| MCF 10A-H2B-mCherry | Etoposide | 24 | 2.0061 | 129.7291 | 0.2052 | -1.0000 | 0.2635 | 0.3116 |
| MCF 10A-H2B-mCherry | Dasatinib | 24 | Inf | Inf | 0.3464 | 0.3464 | 0.0000 | 0.3987 |
| MCF 10A-H2B-mCherry | Taxol | 36 | 0.0017 | 0.0028 | -0.3238 | -0.3277 | 0.9300 | 0.7159 |
| MCF 10A-H2B-mCherry | Vorinostat | 36 | 0.554 | 0.9298 | -0.0652 | -0.2551 | 0.7961 | 0.4258 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.1462 | 0.1855 | 0.2073 | -0.0474 | 0.3804 | 0.3953 |
| MCF 10A-H2B-mCherry | Palbociclib | 36 | 8.2546 | 999.9626 | 0.4151 | -0.4519 | 0.1342 | 0.3252 |
| MCF 10A-H2B-mCherry | Alpelisib | 36 | Inf | Inf | 0.6884 | 0.6884 | 0.0000 | 0.1933 |
| MCF 10A-H2B-mCherry | Dasatinib | 36 | 1.8278 | 999.8676 | 0.3368 | -0.9426 | 0.1681 | 0.3611 |
| MCF 10A-H2B-mCherry | Trametinib | 36 | Inf | 0.0001 | 0.5993 | 0.6033 | 0.5390 | 0.3548 |
| MCF 10A-H2B-mCherry | Etoposide | 36 | 1.5954 | 57.0859 | 0.1922 | -1.0000 | 0.3071 | 0.3079 |
| MCF 10A-H2B-mCherry | Taxol | 48 | 0.0013 | 0.0019 | -0.3312 | -0.2815 | 1.1758 | 0.7519 |