LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 9 of 15: End-point dose-response metrics for biological replicate 3. - Dataset (ID:20317)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 36 | Inf | 0.0001 | 0.5993 | 0.6033 | 0.5390 | 0.3548 |
| MCF 10A-H2B-mCherry | Trametinib | 48 | Inf | 0.0005 | 0.5447 | 0.5288 | 0.5177 | 0.3751 |
| MCF 10A-H2B-mCherry | Taxol | 84 | 0.0009 | 0.0012 | -0.3444 | -0.2890 | 1.3812 | 0.8153 |
| MCF 10A-H2B-mCherry | Taxol | 72 | 0.001 | 0.0013 | -0.3180 | -0.2585 | 1.4036 | 0.7880 |
| MCF 10A-H2B-mCherry | Taxol | 60 | 0.0011 | 0.0014 | -0.3195 | -0.2487 | 1.3756 | 0.7703 |
| MCF 10A-H2B-mCherry | Trametinib | 60 | 0.2951 | 0.0015 | 0.5078 | 0.4730 | 0.5502 | 0.3764 |
| MCF 10A-H2B-mCherry | Taxol | 48 | 0.0013 | 0.0019 | -0.3312 | -0.2815 | 1.1758 | 0.7519 |
| MCF 10A-H2B-mCherry | Taxol | 36 | 0.0017 | 0.0028 | -0.3238 | -0.3277 | 0.9300 | 0.7159 |
| MCF 10A-H2B-mCherry | Trametinib | 72 | 0.0717 | 0.0063 | 0.3482 | 0.3285 | 0.4390 | 0.3784 |
| MCF 10A-H2B-mCherry | Taxol | 24 | 0.002 | 0.0084 | -0.2083 | -0.5081 | 0.4902 | 0.6573 |
| MCF 10A-H2B-mCherry | Neratinib | 24 | 0.0809 | 0.0088 | 0.2144 | 0.3494 | 0.5423 | 0.4143 |
| MCF 10A-H2B-mCherry | Trametinib | 84 | 0.1232 | 0.0231 | 0.3664 | 0.2222 | 0.3508 | 0.3587 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.1462 | 0.1855 | 0.2073 | -0.0474 | 0.3804 | 0.3953 |
| MCF 10A-H2B-mCherry | Etoposide | 84 | 0.3533 | 0.6359 | 0.1344 | -0.1515 | 0.4501 | 0.4060 |
| MCF 10A-H2B-mCherry | Vorinostat | 36 | 0.554 | 0.9298 | -0.0652 | -0.2551 | 0.7961 | 0.4258 |
| MCF 10A-H2B-mCherry | Vorinostat | 48 | 0.6114 | 0.9444 | -0.0821 | -0.2429 | 0.9107 | 0.4110 |
| MCF 10A-H2B-mCherry | Dasatinib | 60 | 1.0757 | 102.3859 | 0.1735 | -1.0000 | 0.2412 | 0.3555 |
| MCF 10A-H2B-mCherry | Vorinostat | 60 | 0.7223 | 1.0618 | -0.0810 | -0.2268 | 0.9711 | 0.3866 |
| MCF 10A-H2B-mCherry | Vorinostat | 72 | 0.8282 | 1.127 | -0.0873 | -0.2023 | 1.1031 | 0.3632 |
| MCF 10A-H2B-mCherry | Vorinostat | 84 | 0.8613 | 1.1591 | -0.0588 | -0.1971 | 1.1191 | 0.3611 |
| MCF 10A-H2B-mCherry | Etoposide | 72 | 0.5612 | 1.2244 | 0.1419 | -0.2015 | 0.4341 | 0.3610 |
| MCF 10A-H2B-mCherry | Etoposide | 24 | 2.0061 | 129.7291 | 0.2052 | -1.0000 | 0.2635 | 0.3116 |
| MCF 10A-H2B-mCherry | Palbociclib | 84 | 2.3696 | 134.4749 | 0.1665 | -1.0000 | 0.2720 | 0.2965 |
| MCF 10A-H2B-mCherry | Etoposide | 60 | 0.847 | 16.3367 | 0.1412 | -0.8621 | 0.3387 | 0.3416 |
| MCF 10A-H2B-mCherry | Vorinostat | 24 | 0.4754 | 1.7724 | -0.0276 | -0.4821 | 0.5130 | 0.4423 |