LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 9 of 15: End-point dose-response metrics for biological replicate 3. - Dataset (ID:20317)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 12 | Inf | Inf | 0.6300 | 0.6300 | 0.0000 | 0.3905 |
| MCF 10A-H2B-mCherry | Alpelisib | 24 | Inf | Inf | 0.6568 | 0.6568 | 0.0000 | 0.2481 |
| MCF 10A-H2B-mCherry | Alpelisib | 36 | Inf | Inf | 0.6884 | 0.6884 | 0.0000 | 0.1933 |
| MCF 10A-H2B-mCherry | Alpelisib | 48 | Inf | Inf | 0.7129 | 0.7129 | 0.0000 | 0.1620 |
| MCF 10A-H2B-mCherry | Alpelisib | 60 | Inf | Inf | 0.7342 | 0.7342 | 0.0000 | 0.1444 |
| MCF 10A-H2B-mCherry | Alpelisib | 72 | Inf | Inf | 0.7448 | 0.7448 | 0.0000 | 0.1385 |
| MCF 10A-H2B-mCherry | Alpelisib | 84 | Inf | Inf | 0.7193 | 0.7193 | 0.0000 | 0.1230 |
| MCF 10A-H2B-mCherry | Dasatinib | 12 | Inf | Inf | 0.3669 | 0.3669 | 0.0000 | 0.4736 |
| MCF 10A-H2B-mCherry | Dasatinib | 24 | Inf | Inf | 0.3464 | 0.3464 | 0.0000 | 0.3987 |
| MCF 10A-H2B-mCherry | Dasatinib | 36 | 1.8278 | 999.8676 | 0.3368 | -0.9426 | 0.1681 | 0.3611 |
| MCF 10A-H2B-mCherry | Dasatinib | 48 | 1.2987 | 299.0185 | 0.3294 | -1.0000 | 0.2020 | 0.3592 |
| MCF 10A-H2B-mCherry | Dasatinib | 60 | 1.0757 | 102.3859 | 0.1735 | -1.0000 | 0.2412 | 0.3555 |
| MCF 10A-H2B-mCherry | Dasatinib | 72 | 0.8672 | 64.7283 | 0.0603 | -1.0000 | 0.2547 | 0.3653 |
| MCF 10A-H2B-mCherry | Dasatinib | 84 | 0.5642 | 58.6317 | -0.0543 | -1.0000 | 0.2366 | 0.3960 |
| MCF 10A-H2B-mCherry | Etoposide | 12 | Inf | Inf | 0.3340 | 0.3340 | 0.0000 | 0.4725 |
| MCF 10A-H2B-mCherry | Etoposide | 24 | 2.0061 | 129.7291 | 0.2052 | -1.0000 | 0.2635 | 0.3116 |
| MCF 10A-H2B-mCherry | Etoposide | 36 | 1.5954 | 57.0859 | 0.1922 | -1.0000 | 0.3071 | 0.3079 |
| MCF 10A-H2B-mCherry | Etoposide | 48 | 1.1834 | 37.3253 | 0.1896 | -1.0000 | 0.3183 | 0.3192 |
| MCF 10A-H2B-mCherry | Etoposide | 60 | 0.847 | 16.3367 | 0.1412 | -0.8621 | 0.3387 | 0.3416 |
| MCF 10A-H2B-mCherry | Etoposide | 72 | 0.5612 | 1.2244 | 0.1419 | -0.2015 | 0.4341 | 0.3610 |
| MCF 10A-H2B-mCherry | Etoposide | 84 | 0.3533 | 0.6359 | 0.1344 | -0.1515 | 0.4501 | 0.4060 |
| MCF 10A-H2B-mCherry | Neratinib | 12 | Inf | Inf | 0.2348 | 0.2348 | 0.0000 | 0.4770 |
| MCF 10A-H2B-mCherry | Neratinib | 24 | 0.0809 | 0.0088 | 0.2144 | 0.3494 | 0.5423 | 0.4143 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.1462 | 0.1855 | 0.2073 | -0.0474 | 0.3804 | 0.3953 |
| MCF 10A-H2B-mCherry | Neratinib | 48 | 0.1895 | 4.5797 | 0.0307 | -1.0000 | 0.3449 | 0.3845 |