LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 7 of 15: End-point dose-response metrics for biological replicate 1. - Dataset (ID:20315)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 14 | Inf | 1.3563 | 0.7546 | 0.8330 | 4.9988 | 0.0207 |
| MCF 10A-H2B-mCherry | Alpelisib | 60 | 26.0457 | 109.4817 | 0.6959 | -0.8810 | 0.7075 | 0.0512 |
| MCF 10A-H2B-mCherry | Alpelisib | 85 | 38.4875 | 239.7081 | 0.7147 | -0.9999 | 0.6006 | 0.0545 |
| MCF 10A-H2B-mCherry | Alpelisib | 25 | Inf | 1.4330 | 0.6573 | 0.7499 | 5.0000 | 0.0556 |
| MCF 10A-H2B-mCherry | Alpelisib | 49 | 24.7897 | 113.5315 | 0.6824 | -0.9254 | 0.6885 | 0.0557 |
| MCF 10A-H2B-mCherry | Alpelisib | 74 | 31.5401 | 177.9526 | 0.7039 | -1.0000 | 0.6349 | 0.0560 |
| MCF 10A-H2B-mCherry | Alpelisib | 36 | 29.4183 | 34.2284 | 0.6713 | -0.0572 | 0.7153 | 0.0579 |
| MCF 10A-H2B-mCherry | Trametinib | 14 | Inf | 0.0076 | 0.7513 | 0.8546 | 4.9986 | 0.0689 |
| MCF 10A-H2B-mCherry | Dasatinib | 14 | 7.4345 | 45.0580 | 0.4382 | -0.6543 | 0.4643 | 0.1430 |
| MCF 10A-H2B-mCherry | Neratinib | 14 | Inf | 0.0623 | 0.5705 | 0.6446 | 5.0000 | 0.1630 |
| MCF 10A-H2B-mCherry | Palbociclib | 14 | Inf | 0.0470 | 0.6055 | 0.6286 | 2.3771 | 0.2335 |
| MCF 10A-H2B-mCherry | Etoposide | 14 | 0.9278 | 0.8558 | 0.0750 | 0.0630 | 1.6679 | 0.2602 |
| MCF 10A-H2B-mCherry | Dasatinib | 25 | 0.7437 | 0.2076 | 0.2558 | 0.3396 | 0.8909 | 0.2675 |
| MCF 10A-H2B-mCherry | Vorinostat | 14 | 1.2267 | 0.9430 | 0.1980 | 0.1308 | 1.1529 | 0.2691 |
| MCF 10A-H2B-mCherry | Vorinostat | 85 | 1.307 | 1.3899 | -0.0587 | -0.0691 | 2.1072 | 0.2776 |
| MCF 10A-H2B-mCherry | Vorinostat | 74 | 1.2172 | 1.3203 | -0.0640 | -0.0849 | 1.9279 | 0.2897 |
| MCF 10A-H2B-mCherry | Dasatinib | 85 | 1.1883 | 11.0713 | -0.0204 | -1.0000 | 0.4922 | 0.2947 |
| MCF 10A-H2B-mCherry | Dasatinib | 36 | 0.7304 | 0.5300 | 0.1489 | 0.0939 | 0.6483 | 0.2962 |
| MCF 10A-H2B-mCherry | Dasatinib | 74 | 1.127 | 11.8661 | 0.0188 | -1.0000 | 0.4667 | 0.2978 |
| MCF 10A-H2B-mCherry | Dasatinib | 60 | 0.9634 | 4.3329 | 0.0547 | -0.5493 | 0.4931 | 0.3012 |
| MCF 10A-H2B-mCherry | Dasatinib | 49 | 0.7746 | 1.1082 | 0.0954 | -0.1144 | 0.5751 | 0.3048 |
| MCF 10A-H2B-mCherry | Etoposide | 25 | 0.6735 | 0.6909 | 0.0421 | -0.0166 | 1.2824 | 0.3073 |
| MCF 10A-H2B-mCherry | Vorinostat | 60 | 1.0712 | 1.2024 | -0.0684 | -0.1062 | 1.6672 | 0.3109 |
| MCF 10A-H2B-mCherry | Neratinib | 85 | 0.2047 | 0.2231 | -0.0133 | -0.0516 | 1.1390 | 0.3213 |
| MCF 10A-H2B-mCherry | Etoposide | 36 | 0.542 | 0.5522 | 0.0298 | -0.0120 | 1.2808 | 0.3248 |