LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 7 of 15: End-point dose-response metrics for biological replicate 1. - Dataset (ID:20315)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Palbociclib | 14 | Inf | 0.0470 | 0.6055 | 0.6286 | 2.3771 | 0.2335 |
| MCF 10A-H2B-mCherry | Dasatinib | 14 | 7.4345 | 45.0580 | 0.4382 | -0.6543 | 0.4643 | 0.1430 |
| MCF 10A-H2B-mCherry | Vorinostat | 14 | 1.2267 | 0.9430 | 0.1980 | 0.1308 | 1.1529 | 0.2691 |
| MCF 10A-H2B-mCherry | Taxol | 14 | 0.0086 | 0.0094 | -0.3292 | -0.2527 | 5.0000 | 0.4921 |
| MCF 10A-H2B-mCherry | Alpelisib | 14 | Inf | 1.3563 | 0.7546 | 0.8330 | 4.9988 | 0.0207 |
| MCF 10A-H2B-mCherry | Etoposide | 14 | 0.9278 | 0.8558 | 0.0750 | 0.0630 | 1.6679 | 0.2602 |
| MCF 10A-H2B-mCherry | Neratinib | 14 | Inf | 0.0623 | 0.5705 | 0.6446 | 5.0000 | 0.1630 |
| MCF 10A-H2B-mCherry | Trametinib | 14 | Inf | 0.0076 | 0.7513 | 0.8546 | 4.9986 | 0.0689 |
| MCF 10A-H2B-mCherry | Taxol | 25 | 0.006 | 0.0088 | -0.5788 | -0.5111 | 1.8512 | 0.6091 |
| MCF 10A-H2B-mCherry | Trametinib | 25 | 0.0129 | 0.0032 | 0.4248 | 0.4682 | 1.9686 | 0.3579 |
| MCF 10A-H2B-mCherry | Alpelisib | 25 | Inf | 1.4330 | 0.6573 | 0.7499 | 5.0000 | 0.0556 |
| MCF 10A-H2B-mCherry | Vorinostat | 25 | 0.7805 | 1.0475 | -0.0221 | -0.1584 | 0.9356 | 0.3490 |
| MCF 10A-H2B-mCherry | Palbociclib | 25 | 0.1608 | 0.0623 | 0.3195 | 0.3100 | 1.0196 | 0.4040 |
| MCF 10A-H2B-mCherry | Neratinib | 25 | 0.0623 | 0.0324 | 0.3130 | 0.3244 | 1.6032 | 0.3411 |
| MCF 10A-H2B-mCherry | Etoposide | 25 | 0.6735 | 0.6909 | 0.0421 | -0.0166 | 1.2824 | 0.3073 |
| MCF 10A-H2B-mCherry | Dasatinib | 25 | 0.7437 | 0.2076 | 0.2558 | 0.3396 | 0.8909 | 0.2675 |
| MCF 10A-H2B-mCherry | Taxol | 36 | 0.0036 | 0.0060 | -0.6322 | -0.5696 | 1.4542 | 0.6936 |
| MCF 10A-H2B-mCherry | Vorinostat | 36 | 0.8145 | 0.9868 | -0.0499 | -0.1303 | 1.2067 | 0.3492 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.0691 | 0.0508 | 0.1855 | 0.1913 | 1.5671 | 0.3705 |
| MCF 10A-H2B-mCherry | Palbociclib | 36 | 0.216 | 0.1111 | 0.2237 | 0.2190 | 0.8662 | 0.3977 |
| MCF 10A-H2B-mCherry | Alpelisib | 36 | 29.4183 | 34.2284 | 0.6713 | -0.0572 | 0.7153 | 0.0579 |
| MCF 10A-H2B-mCherry | Dasatinib | 36 | 0.7304 | 0.5300 | 0.1489 | 0.0939 | 0.6483 | 0.2962 |
| MCF 10A-H2B-mCherry | Trametinib | 36 | 0.0058 | 0.0031 | 0.2898 | 0.3109 | 1.5832 | 0.4664 |
| MCF 10A-H2B-mCherry | Etoposide | 36 | 0.542 | 0.5522 | 0.0298 | -0.0120 | 1.2808 | 0.3248 |
| MCF 10A-H2B-mCherry | Taxol | 49 | 0.0026 | 0.0045 | -0.5907 | -0.5232 | 1.3137 | 0.7187 |