LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 7 of 15: End-point dose-response metrics for biological replicate 1. - Dataset (ID:20315)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Taxol | 49 | 0.0026 | 0.0045 | -0.5907 | -0.5232 | 1.3137 | 0.7187 |
| MCF 10A-H2B-mCherry | Taxol | 60 | 0.0024 | 0.0038 | -0.5376 | -0.4605 | 1.4197 | 0.7151 |
| MCF 10A-H2B-mCherry | Taxol | 85 | 0.0023 | 0.0033 | -0.4886 | -0.4051 | 1.6490 | 0.7131 |
| MCF 10A-H2B-mCherry | Taxol | 74 | 0.0023 | 0.0034 | -0.4930 | -0.4115 | 1.5424 | 0.7101 |
| MCF 10A-H2B-mCherry | Taxol | 36 | 0.0036 | 0.0060 | -0.6322 | -0.5696 | 1.4542 | 0.6936 |
| MCF 10A-H2B-mCherry | Taxol | 25 | 0.006 | 0.0088 | -0.5788 | -0.5111 | 1.8512 | 0.6091 |
| MCF 10A-H2B-mCherry | Trametinib | 49 | 0.0066 | 0.0040 | 0.2185 | 0.2369 | 1.2900 | 0.4933 |
| MCF 10A-H2B-mCherry | Taxol | 14 | 0.0086 | 0.0094 | -0.3292 | -0.2527 | 5.0000 | 0.4921 |
| MCF 10A-H2B-mCherry | Trametinib | 60 | 0.0078 | 0.0050 | 0.1929 | 0.2064 | 1.1997 | 0.4918 |
| MCF 10A-H2B-mCherry | Trametinib | 74 | 0.0093 | 0.0062 | 0.1778 | 0.1846 | 1.1445 | 0.4863 |
| MCF 10A-H2B-mCherry | Trametinib | 85 | 0.0112 | 0.0077 | 0.1723 | 0.1730 | 1.1413 | 0.4734 |
| MCF 10A-H2B-mCherry | Trametinib | 36 | 0.0058 | 0.0031 | 0.2898 | 0.3109 | 1.5832 | 0.4664 |
| MCF 10A-H2B-mCherry | Palbociclib | 25 | 0.1608 | 0.0623 | 0.3195 | 0.3100 | 1.0196 | 0.4040 |
| MCF 10A-H2B-mCherry | Palbociclib | 36 | 0.216 | 0.1111 | 0.2237 | 0.2190 | 0.8662 | 0.3977 |
| MCF 10A-H2B-mCherry | Palbociclib | 49 | 0.2432 | 0.1490 | 0.1924 | 0.1866 | 0.9531 | 0.3867 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.0691 | 0.0508 | 0.1855 | 0.1913 | 1.5671 | 0.3705 |
| MCF 10A-H2B-mCherry | Palbociclib | 60 | 0.308 | 0.1983 | 0.1719 | 0.1611 | 0.8830 | 0.3696 |
| MCF 10A-H2B-mCherry | Trametinib | 25 | 0.0129 | 0.0032 | 0.4248 | 0.4682 | 1.9686 | 0.3579 |
| MCF 10A-H2B-mCherry | Neratinib | 49 | 0.1003 | 0.0824 | 0.1199 | 0.1213 | 1.4136 | 0.3576 |
| MCF 10A-H2B-mCherry | Palbociclib | 74 | 0.3799 | 0.2585 | 0.1562 | 0.1383 | 0.8411 | 0.3557 |
| MCF 10A-H2B-mCherry | Etoposide | 85 | 0.4487 | 0.4530 | 0.0008 | -0.0071 | 1.4840 | 0.3508 |
| MCF 10A-H2B-mCherry | Etoposide | 74 | 0.4441 | 0.4511 | 0.0118 | -0.0110 | 1.3847 | 0.3505 |
| MCF 10A-H2B-mCherry | Vorinostat | 36 | 0.8145 | 0.9868 | -0.0499 | -0.1303 | 1.2067 | 0.3492 |
| MCF 10A-H2B-mCherry | Vorinostat | 25 | 0.7805 | 1.0475 | -0.0221 | -0.1584 | 0.9356 | 0.3490 |
| MCF 10A-H2B-mCherry | Etoposide | 60 | 0.4484 | 0.4561 | 0.0206 | -0.0114 | 1.3240 | 0.3465 |