LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 7 of 15: End-point dose-response metrics for biological replicate 1. - Dataset (ID:20315)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Neratinib | 14 | Inf | 0.0623 | 0.5705 | 0.6446 | 5.0000 | 0.1630 |
| MCF 10A-H2B-mCherry | Taxol | 14 | 0.0086 | 0.0094 | -0.3292 | -0.2527 | 5.0000 | 0.4921 |
| MCF 10A-H2B-mCherry | Alpelisib | 25 | Inf | 1.4330 | 0.6573 | 0.7499 | 5.0000 | 0.0556 |
| MCF 10A-H2B-mCherry | Alpelisib | 14 | Inf | 1.3563 | 0.7546 | 0.8330 | 4.9988 | 0.0207 |
| MCF 10A-H2B-mCherry | Trametinib | 14 | Inf | 0.0076 | 0.7513 | 0.8546 | 4.9986 | 0.0689 |
| MCF 10A-H2B-mCherry | Palbociclib | 14 | Inf | 0.0470 | 0.6055 | 0.6286 | 2.3771 | 0.2335 |
| MCF 10A-H2B-mCherry | Vorinostat | 85 | 1.307 | 1.3899 | -0.0587 | -0.0691 | 2.1072 | 0.2776 |
| MCF 10A-H2B-mCherry | Trametinib | 25 | 0.0129 | 0.0032 | 0.4248 | 0.4682 | 1.9686 | 0.3579 |
| MCF 10A-H2B-mCherry | Vorinostat | 74 | 1.2172 | 1.3203 | -0.0640 | -0.0849 | 1.9279 | 0.2897 |
| MCF 10A-H2B-mCherry | Taxol | 25 | 0.006 | 0.0088 | -0.5788 | -0.5111 | 1.8512 | 0.6091 |
| MCF 10A-H2B-mCherry | Etoposide | 14 | 0.9278 | 0.8558 | 0.0750 | 0.0630 | 1.6679 | 0.2602 |
| MCF 10A-H2B-mCherry | Vorinostat | 60 | 1.0712 | 1.2024 | -0.0684 | -0.1062 | 1.6672 | 0.3109 |
| MCF 10A-H2B-mCherry | Taxol | 85 | 0.0023 | 0.0033 | -0.4886 | -0.4051 | 1.6490 | 0.7131 |
| MCF 10A-H2B-mCherry | Neratinib | 25 | 0.0623 | 0.0324 | 0.3130 | 0.3244 | 1.6032 | 0.3411 |
| MCF 10A-H2B-mCherry | Trametinib | 36 | 0.0058 | 0.0031 | 0.2898 | 0.3109 | 1.5832 | 0.4664 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.0691 | 0.0508 | 0.1855 | 0.1913 | 1.5671 | 0.3705 |
| MCF 10A-H2B-mCherry | Taxol | 74 | 0.0023 | 0.0034 | -0.4930 | -0.4115 | 1.5424 | 0.7101 |
| MCF 10A-H2B-mCherry | Etoposide | 85 | 0.4487 | 0.4530 | 0.0008 | -0.0071 | 1.4840 | 0.3508 |
| MCF 10A-H2B-mCherry | Taxol | 36 | 0.0036 | 0.0060 | -0.6322 | -0.5696 | 1.4542 | 0.6936 |
| MCF 10A-H2B-mCherry | Vorinostat | 49 | 0.9385 | 1.0915 | -0.0683 | -0.1220 | 1.4457 | 0.3318 |
| MCF 10A-H2B-mCherry | Taxol | 60 | 0.0024 | 0.0038 | -0.5376 | -0.4605 | 1.4197 | 0.7151 |
| MCF 10A-H2B-mCherry | Neratinib | 49 | 0.1003 | 0.0824 | 0.1199 | 0.1213 | 1.4136 | 0.3576 |
| MCF 10A-H2B-mCherry | Neratinib | 60 | 0.1262 | 0.1133 | 0.0711 | 0.0699 | 1.4052 | 0.3452 |
| MCF 10A-H2B-mCherry | Etoposide | 74 | 0.4441 | 0.4511 | 0.0118 | -0.0110 | 1.3847 | 0.3505 |
| MCF 10A-H2B-mCherry | Etoposide | 60 | 0.4484 | 0.4561 | 0.0206 | -0.0114 | 1.3240 | 0.3465 |