Phosphorylation state and protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (immunofluorescence dataset 4 of 4) - Dataset (ID:20277)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Primary Antibody (488) Secondary Antibody (488) Protein Detected (488) Mean Fluorescence Intensity (488) Primary Antibody (647) Secondary Antibody (647) Protein 1 Detected (647) Protein 2 Detected (647) Protein 3 Detected (647) Protein 4 Detected (647) Mean Fluorescence Intensity (647) Plate Name Plate Well
WM-115 Vemurafenib Trametinib 1.000 0.200
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 -1.15 NGFR rabbit IgG(H+L) / donkey NGFR 2136.86
WM115-P3
B10
WM-115 Vemurafenib Trametinib 3.160 0.200
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 -40.12 NGFR rabbit IgG(H+L) / donkey NGFR 1602.91
WM115-P3
B11
WM-115 Vemurafenib 0.000
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 326.59 NGFR rabbit IgG(H+L) / donkey NGFR 765.92
WM115-P3
B2
WM-115 Vemurafenib 0.100
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 237.21 NGFR rabbit IgG(H+L) / donkey NGFR 1002.93
WM115-P3
B3
WM-115 Vemurafenib 0.316
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 174.85 NGFR rabbit IgG(H+L) / donkey NGFR 1317.40
WM115-P3
B4
WM-115 Vemurafenib 1.000
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 115.31 NGFR rabbit IgG(H+L) / donkey NGFR 1535.07
WM115-P3
B5
WM-115 Vemurafenib 3.160
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 88.70 NGFR rabbit IgG(H+L) / donkey NGFR 1619.14
WM115-P3
B6
WM-115 Vemurafenib Trametinib 0.000 0.200
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 87.23 NGFR rabbit IgG(H+L) / donkey NGFR 2203.80
WM115-P3
B7
WM-115 Vemurafenib Trametinib 0.100 0.200
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 111.82 NGFR rabbit IgG(H+L) / donkey NGFR 2227.68
WM115-P3
B8
WM-115 Vemurafenib Trametinib 0.316 0.200
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 27.62 NGFR rabbit IgG(H+L) / donkey NGFR 2069.76
WM115-P3
B9
WM-115 Vemurafenib Trametinib 1.000 0.200
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 17.89 NGFR rabbit IgG(H+L) / donkey NGFR 2160.41
WM115-P3
C10
WM-115 Vemurafenib Trametinib 3.160 0.200
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 2.89 NGFR rabbit IgG(H+L) / donkey NGFR 1658.33
WM115-P3
C11
WM-115 Vemurafenib 0.000
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 318.12 NGFR rabbit IgG(H+L) / donkey NGFR 640.72
WM115-P3
C2
WM-115 Vemurafenib 0.100
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 221.85 NGFR rabbit IgG(H+L) / donkey NGFR 929.98
WM115-P3
C3
WM-115 Vemurafenib 0.316
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 152.52 NGFR rabbit IgG(H+L) / donkey NGFR 1249.68
WM115-P3
C4
WM-115 Vemurafenib 1.000
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 74.57 NGFR rabbit IgG(H+L) / donkey NGFR 1577.58
WM115-P3
C5
WM-115 Vemurafenib 3.160
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 13.63 NGFR rabbit IgG(H+L) / donkey NGFR 1481.80
WM115-P3
C6
WM-115 Vemurafenib Trametinib 0.000 0.200
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 30.45 NGFR rabbit IgG(H+L) / donkey NGFR 2109.94
WM115-P3
C7
WM-115 Vemurafenib Trametinib 0.100 0.200
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 60.13 NGFR rabbit IgG(H+L) / donkey NGFR 2045.24
WM115-P3
C8
WM-115 Vemurafenib Trametinib 0.316 0.200
uM
 48
hr
 2 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 65.07 NGFR rabbit IgG(H+L) / donkey NGFR 2077.24
WM115-P3
C9
WM-115 Vemurafenib I-BET 1.000 1.000
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 34.81 NGFR rabbit IgG(H+L) / donkey NGFR 1187.71
WM115-P3
D10
WM-115 Vemurafenib I-BET 3.160 1.000
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 5.32 NGFR rabbit IgG(H+L) / donkey NGFR 843.16
WM115-P3
D11
WM-115 Vemurafenib Belinostat 0.000 1.000
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 160.34 NGFR rabbit IgG(H+L) / donkey NGFR 908.82
WM115-P3
D2
WM-115 Vemurafenib Belinostat 0.100 1.000
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 132.65 NGFR rabbit IgG(H+L) / donkey NGFR 870.13
WM115-P3
D3
WM-115 Vemurafenib Belinostat 0.316 1.000
uM
 48
hr
 1 KI-67 / clone 8D5 mouse IgG(H+L) / donkey KI-67 92.49 NGFR rabbit IgG(H+L) / donkey NGFR 771.16
WM115-P3
D4