Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib I-BET151 0.316 1.000
uM
 72
hr
 1 1276 733 0.1255 0.1085 0.5745 0.5981
COLO 858 Vemurafenib I-BET151 0.316 1.000
uM
 72
hr
 2 1178 702 0.1100 0.1085 0.5959 0.5981
COLO 858 Vemurafenib I-BET151 0.316 1.000
uM
 72
hr
 3 1034 645 0.0899 0.1085 0.6238 0.5981
COLO 858 Vemurafenib I-BET151 1.000 0.000
uM
 72
hr
 1 1055 482 0.1324 0.1445 0.4569 0.4584
COLO 858 Vemurafenib I-BET151 1.000 0.000
uM
 72
hr
 2 1148 502 0.1493 0.1445 0.4373 0.4584
COLO 858 Vemurafenib I-BET151 1.000 0.000
uM
 72
hr
 3 1266 609 0.1518 0.1445 0.4810 0.4584
COLO 858 Vemurafenib I-BET151 1.000 1.000
uM
 72
hr
 1 1426 1073 0.0816 0.0720 0.7525 0.7523
COLO 858 Vemurafenib I-BET151 1.000 1.000
uM
 72
hr
 2 1278 957 0.0742 0.0720 0.7488 0.7523
COLO 858 Vemurafenib I-BET151 1.000 1.000
uM
 72
hr
 3 1068 807 0.0603 0.0720 0.7556 0.7523
COLO 858 Vemurafenib I-BET151 3.160 0.000
uM
 72
hr
 1 1039 854 0.0428 0.0449 0.8219 0.8382
COLO 858 Vemurafenib I-BET151 3.160 0.000
uM
 72
hr
 2 1213 1019 0.0448 0.0449 0.8401 0.8382
COLO 858 Vemurafenib I-BET151 3.160 0.000
uM
 72
hr
 3 1385 1181 0.0471 0.0449 0.8527 0.8382
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 1 1460 1042 0.0966 0.0871 0.7137 0.7176
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 2 1381 996 0.0890 0.0871 0.7212 0.7176
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 3 1163 835 0.0758 0.0871 0.7180 0.7176
WM-115 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 1 3640 233 1.0453 1.0000 0.0640 0.0538
WM-115 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 2 3366 157 0.9846 1.0000 0.0466 0.0538
WM-115 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 3 3331 169 0.9701 1.0000 0.0507 0.0538
WM-115 Vemurafenib (+)-JQ1 0.000 1.000
uM
 72
hr
 1 2536 154 0.7308 0.6798 0.0607 0.0674
WM-115 Vemurafenib (+)-JQ1 0.000 1.000
uM
 72
hr
 2 2283 159 0.6517 0.6798 0.0696 0.0674
WM-115 Vemurafenib (+)-JQ1 0.000 1.000
uM
 72
hr
 3 2307 166 0.6569 0.6798 0.0720 0.0674
WM-115 Vemurafenib (+)-JQ1 0.100 0.000
uM
 72
hr
 1 3365 184 0.9760 0.9612 0.0547 0.0512
WM-115 Vemurafenib (+)-JQ1 0.100 0.000
uM
 72
hr
 2 3302 145 0.9686 0.9612 0.0439 0.0512
WM-115 Vemurafenib (+)-JQ1 0.100 0.000
uM
 72
hr
 3 3239 178 0.9391 0.9612 0.0550 0.0512
WM-115 Vemurafenib (+)-JQ1 0.100 1.000
uM
 72
hr
 1 1859 768 0.3347 0.3130 0.4131 0.4335