Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
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A-375 | Vemurafenib | Defactinib | 1.000 | 0.316 | uM | 72 | hr | 2 | 3261 | 223 | 0.1456 | 0.1394 | 0.0684 | 0.0554 |
A-375 | Vemurafenib | Defactinib | 1.000 | 0.316 | uM | 72 | hr | 3 | 3044 | 145 | 0.1389 | 0.1394 | 0.0476 | 0.0554 |
A-375 | Vemurafenib | Defactinib | 1.000 | 1.000 | uM | 72 | hr | 1 | 2592 | 213 | 0.1140 | 0.1060 | 0.0822 | 0.0803 |
A-375 | Vemurafenib | Defactinib | 1.000 | 1.000 | uM | 72 | hr | 2 | 2479 | 188 | 0.1098 | 0.1060 | 0.0758 | 0.0803 |
A-375 | Vemurafenib | Defactinib | 1.000 | 1.000 | uM | 72 | hr | 3 | 2145 | 178 | 0.0943 | 0.1060 | 0.0830 | 0.0803 |
A-375 | Vemurafenib | Defactinib | 1.000 | 3.160 | uM | 72 | hr | 1 | 1436 | 338 | 0.0526 | 0.0534 | 0.2354 | 0.2441 |
A-375 | Vemurafenib | Defactinib | 1.000 | 3.160 | uM | 72 | hr | 2 | 1579 | 390 | 0.0570 | 0.0534 | 0.2470 | 0.2441 |
A-375 | Vemurafenib | Defactinib | 1.000 | 3.160 | uM | 72 | hr | 3 | 1408 | 352 | 0.0506 | 0.0534 | 0.2500 | 0.2441 |
A-375 | Vemurafenib | Defactinib | 3.160 | 0.000 | uM | 72 | hr | 1 | 2887 | 241 | 0.1268 | 0.1293 | 0.0835 | 0.0864 |
A-375 | Vemurafenib | Defactinib | 3.160 | 0.000 | uM | 72 | hr | 2 | 2966 | 270 | 0.1292 | 0.1293 | 0.0910 | 0.0864 |
A-375 | Vemurafenib | Defactinib | 3.160 | 0.000 | uM | 72 | hr | 3 | 3008 | 255 | 0.1319 | 0.1293 | 0.0848 | 0.0864 |
A-375 | Vemurafenib | Defactinib | 3.160 | 0.316 | uM | 72 | hr | 1 | 2320 | 269 | 0.0983 | 0.1027 | 0.1159 | 0.1177 |
A-375 | Vemurafenib | Defactinib | 3.160 | 0.316 | uM | 72 | hr | 2 | 2487 | 272 | 0.1062 | 0.1027 | 0.1094 | 0.1177 |
A-375 | Vemurafenib | Defactinib | 3.160 | 0.316 | uM | 72 | hr | 3 | 2479 | 317 | 0.1036 | 0.1027 | 0.1279 | 0.1177 |
A-375 | Vemurafenib | Defactinib | 3.160 | 1.000 | uM | 72 | hr | 1 | 2292 | 344 | 0.0934 | 0.0857 | 0.1501 | 0.1490 |
A-375 | Vemurafenib | Defactinib | 3.160 | 1.000 | uM | 72 | hr | 2 | 2192 | 327 | 0.0894 | 0.0857 | 0.1492 | 0.1490 |
A-375 | Vemurafenib | Defactinib | 3.160 | 1.000 | uM | 72 | hr | 3 | 1822 | 269 | 0.0744 | 0.0857 | 0.1476 | 0.1490 |
A-375 | Vemurafenib | Defactinib | 3.160 | 3.160 | uM | 72 | hr | 1 | 1574 | 486 | 0.0521 | 0.0435 | 0.3088 | 0.3296 |
A-375 | Vemurafenib | Defactinib | 3.160 | 3.160 | uM | 72 | hr | 2 | 1336 | 436 | 0.0431 | 0.0435 | 0.3263 | 0.3296 |
A-375 | Vemurafenib | Defactinib | 3.160 | 3.160 | uM | 72 | hr | 3 | 1142 | 404 | 0.0354 | 0.0435 | 0.3538 | 0.3296 |
A-375 | Vemurafenib | JNK-IN-8 | 0.000 | 0.000 | uM | 72 | hr | 1 | 17029 | 767 | 1.0229 | 1.0000 | 0.0450 | 0.0476 |
A-375 | Vemurafenib | JNK-IN-8 | 0.000 | 0.000 | uM | 72 | hr | 2 | 16317 | 808 | 0.9755 | 1.0000 | 0.0495 | 0.0476 |
A-375 | Vemurafenib | JNK-IN-8 | 0.000 | 0.000 | uM | 72 | hr | 3 | 16730 | 807 | 1.0016 | 1.0000 | 0.0482 | 0.0476 |
A-375 | Vemurafenib | JNK-IN-8 | 0.000 | 0.316 | uM | 72 | hr | 1 | 15089 | 638 | 0.9090 | 1.0016 | 0.0423 | 0.0383 |
A-375 | Vemurafenib | JNK-IN-8 | 0.000 | 0.316 | uM | 72 | hr | 2 | 16836 | 650 | 1.0181 | 1.0016 | 0.0386 | 0.0383 |